Recombinant Mouse Chloride intracellular channel protein 4 (Clic4)
-
中文名称:Recombinant Mouse Chloride intracellular channel protein 4(Clic4)
-
货号:CSB-CF882560MO
-
规格:
-
来源:in vitro E.coli expression system
-
其他:
产品详情
-
基因名:Clic4
-
Uniprot No.:
-
别名:Clic4; Chloride intracellular channel protein 4; mc3s5/mtCLIC
-
种属:Mus musculus (Mouse)
-
蛋白长度:Full Length of Mature Protein
-
表达区域:2-253
-
氨基酸序列ALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKR KPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDI FAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRRFLDG DEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVE IAYSDVAKRLTK
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. -
蛋白标签:N-terminal 10xHis-tagged
-
产品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
缓冲液:Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
-
储存条件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
-
保质期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
-
注意事项:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
Datasheet & COA:Please contact us to get it.
相关产品
靶点详情
-
功能:Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis.
-
基因功能参考文献:
- Results demonstrate that down-regulating CLIC4 inhibit the proliferation and promotes the apoptosis of mouse liver cancer Hca-F cell. PMID: 28636115
- Results indicate CLICs (CLIC1, CLIC4 and CLIC5)-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation. PMID: 28779175
- Data, including data from studies in primary cells from knockout mice, suggest Clic1 and Clic4 participate in signaling interleukin 1beta secretion and in activation of Nlrp3 inflammasomes; in LPS macrophage activation, Clic1 and Clic4 are translocated to nucleus/cell membranes. (Clic1 = chloride intracellular channel 1; Clic4 = chloride intracellular channel 4, mitochondrial; Nlrp3 = NLR family pyrin domain containing 3) PMID: 28576828
- The findings indicate that CLIC4/CLIC5A-mediated ERM activation is required for maintenance of the glomerular capillary architecture. PMID: 27582103
- CLIC4 is not required for collaterogenesis but is essential for perinatal maturation of nascent collaterals through a mechanism that supports VEGF signaling. PMID: 26276819
- However, the absence of CLIC4 has no significant impact on the extent of functional recovery or fibrosis following acute injury. PMID: 24708746
- Data suggest that compartmentalized expression of chloride intracellular channel 4 (CLIC4) in specific adult tissues and cells provides a focus to explore potential functions of this protein. PMID: 24886590
- Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension. PMID: 24503951
- These results indicate that CLIC4 participates in skin healing and corneal wound reepithelialization through enhancement of epithelial migration by a mechanism that may involve a compromised TGF-beta pathway. PMID: 22613027
- Data suggest that iNOS-induced nuclear CLIC4 is an essential part of the macrophage deactivation program. PMID: 22474389
- CLIC4 is required for an optimal macrophage response to diverse pathogens. CLIC4-null these findings suggest that CLIC4 is an LPS-induced product that can serve as a positive regulator of LPS signaling PMID: 21469130
- S-nitrosylation governs CLIC4 structure, its association with protein partners, and thus its intracellular distribution PMID: 20504765
- mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53. PMID: 11997498
- mtCLIC is involved in mitochondrial membrane potential generation in mitochondrial DNA-depleted cells. PMID: 12958156
- CLIC4 nuclear translocation is an integral part of the cellular response to stress and may contribute to the initiation of nuclear alterations that are associated with apoptosis. PMID: 14610078
- CLIC4 plays a critical role in angiogenesis by supporting acidification of vacuoles along the cell-hollowing tubulogenic pathway. PMID: 19197003
- CLIC4 specifies native collateral formation, exerting influences upstream of hypoxia-inducible factor-1alpha-VEGF signaling PMID: 19478202
显示更多
收起更多
-
亚细胞定位:Cytoplasm. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus. Cell membrane; Single-pass membrane protein. Mitochondrion.
-
蛋白家族:Chloride channel CLIC family
-
组织特异性:Detected in blood vessels in the retina (at protein level). Expressed to the greatest extent in vivo in heart, lung, liver, kidney, and skin.
-
数据库链接:
KEGG: mmu:29876
STRING: 10090.ENSMUSP00000041453
UniGene: Mm.257765
Most popular with customers
-
Recombinant Paguma larvata Angiotensin-converting enzyme 2 (ACE2), partial (Active)
Express system: Mammalian cell
Species: Paguma larvata (Masked palm civet)
-
Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Poliovirus receptor (PVR) (I340M), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Macaca fascicularis zymogen granule protein 16 homolog B (ZG16B) (Active)
Express system: Mammalian cell
Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
-
Recombinant Human Killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Myosin regulatory light chain 12B(MYL12B) (Active)
Express system: E.coli
Species: Homo sapiens (Human)
-
Recombinant Human Gastric inhibitory polypeptide receptor(GIPR),partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)