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Recombinant Mouse Cadherin-11 (Cdh11)

  • 中文名称：
    Recombinant Mouse Cadherin-11(Cdh11)
  • 货号：
    CSB-CF005036MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Cdh11
  • Uniprot No.：
  • 别名：
    Cdh11; Cad-11; Cadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    54-796
  • 氨基酸序列
    GWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHEIYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGIELFEITTDYETQDGVVKLKKPVDFETKRAYSLKIEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNISVFAAEIHNRHQETKVPVAIRVLDVNDNAPKFAAPYEGFICESDHPKALSNQPIVTVSADDQDDTANGPRFIFSLPPEIMHNPNFTVRDNRDNTAGVYARRGGFSRQKQDFYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能参考文献：
    1. Expression of cadherin-11, an adhesion molecule known to promote cell migration and compaction, was upregulated by intermediate-dose BMP7. BMP7-induced cadherin-11 expression was inhibited by cotreatment with SB203580 and PD98059. PMID: 28867673
    2. data demonstrate an important role for CDH11 in the development of skin fibrosis in Tsk-1 mice. These data add to the growing evidence for the important role of CDH11 in tissue fibrosis and fibrotic disease such as systemic sclerosis PMID: 29112946
    3. stromal fibroblasts expressing cadherin-11 regulate adipose tissue inflammation PMID: 28758901
    4. engagement of CDH11 through homophilic interactions, led to swift activation of the TGF-beta and ROCK pathways as evidenced by phosphorylation of downstream effectors. PMID: 27311482
    5. Loss of CDH11 gene is associated with retinoblastoma. PMID: 27750399
    6. Overexpression of Cad-11 upregulates RhoA and Sox9 to induce calcification and extracellular matrix remodeling in adult aortic valves. PMID: 27312222
    7. Cad-11 depleted cells in culture contained few filopodia, stress fibers, or contact inhibited locomotion PMID: 26188246
    8. rFN/CDHs may induce hMSCs differentiation into osteoblasts and PLGA/collagen nanofibers loaded with rFN/CDHs have potential in bone tissue engineering. PMID: 24844413
    9. Cadherin-11 regulates the expression of TGF-B1 and affects smooth muscle cell differentiation through a pathway that was dependent on TGF-B receptor II. PMID: 24741067
    10. Cadherin-11 may play a role in renal cell carcinoma bone metastasis. PMID: 24587095
    11. Data indicate that Cadherin-11 (CDH11) is increased in cells during normal cerebral cortical development. PMID: 23951053
    12. We also demonstrated that CDH11 acts as an inhibitor of tumour growth, motility and dissemination. PMID: 22374749
    13. CDH11-deficient mice had decreased fibrotic endpoints in the bleomycin model of pulmonary fibrosis compared to wild-type mice. PMID: 21990376
    14. The pattern of haplotype diversity across the quantitative trait loci (QTL) region and expression profiles of QTL genes suggested that of the 12, cadherin 11 (Cdh11) was most likely the causal gene. PMID: 21638317
    15. cad-11 modulates synovial fibroblasts to evoke inflammatory factors that may contribute to the inflammatory process in RA. PMID: 21536877
    16. Cdh2 and Cdh11 are crucial regulators of postnatal skeletal growth and bone mass maintenance, serving overlapping, yet distinct, functions in the osteogenic lineage. PMID: 20605916
    17. Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death PMID: 20421947
    18. Cadherin 11 expression initially appears in motor columns before extending to the whole spinal cord, dorsal root ganglia, and sensory-motor peripheral nerves; later, its expression decreases in nervous tissues and becomes predominant in mesenchymes. PMID: 12139922
    19. Cdh11 in intercellular junctions interconnect dermal papilla cells in developing hair follicles and seem to be responsible for establishment of these junctions. PMID: 12524684
    20. A 2.62 Mbp minimal region of genomic loss of chromosome 16q22 was found in retinoblastoma which contains a hotspot CDH11, implicating CDH11as a potential tumor suppressor gene in retinoblastoma. PMID: 15383628
    21. cadherin-11 directly regulates the differentiation of mesenchymal cells into the cells of the osteo-lineage and the chondro-lineage in a different manner from N-cadherin PMID: 15476585
    22. Cadherin-11 enhanced axon growth and prevented interactions occurring between growing axons, providing evidence for a role of cadherin-11 in the control of growth cone progression. PMID: 15797718
    23. Together, these studies implicate cadherin-11 in synovial tissue and lining layer formation and provide an in vitro system to model fibroblast-like synoviocyte behavior and function in organizing the synovial tissue. PMID: 16651616
    24. synovial cadherin-11 determines the behavior of synovial cells in their proinflammatory and destructive tissue response in inflammatory arthritis PMID: 17255475
    25. Results show that tendon formation in the developing limb requires precise regulation of cell shape via cadherin-11-mediated cell-cell junctions and coaxial alignment of plasma membrane channels in longitudinally stacked cells. PMID: 17562872
    26. the results show a link between Trio activity,Rac1 activation,neuronal organization,and recruitment of Cadherin-11 receptor to form a complex with Trio in hindbrain embryology. PMID: 17898204
    27. fibroblast-like synoviocytes express both N-cadherin and cadherin 11, but they do not coimmunoprecipitate, suggesting these cadherins are not in the same molecular complex PMID: 18383368

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels.
  • 数据库链接：

    KEGG: mmu:12552

    STRING: 10090.ENSMUSP00000074681

    UniGene: Mm.1571