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  4. Recombinant Mouse CD83 antigen (Cd83)

Recombinant Mouse CD83 antigen (Cd83)

  • 中文名称：
    Recombinant Mouse CD83 antigen(Cd83)
  • 货号：
    CSB-CF004962MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Cd83
  • Uniprot No.：
  • 别名：
    Cd83; CD83 antigen; mCD83; CD antigen CD83
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-196
  • 氨基酸序列
    MREVTVACSETADLPCTAPWDPQLSYAVSWAKVSESGTESVELPESKQNSSFEAPRRRAYSLTIQNTTICSSGTYRCALQELGGQRNLSGTVVLKVTGCPKEATESTFRKYRAEAVLLFSLVVFYLTLIIFTCKFARLQSIFPDISKPGTEQAFLPVTSPSKHLGPVTLPKTETV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
  • 基因功能参考文献：
    1. orchestrated regulation of MHC II surface expression in thymic epithelial cells (TECs) by MARCH 8 and CD83 plays a major role in CD4(+) T cell selection. PMID: 27503069
    2. CD83-mediated MHCII stabilization through antagonism of March8 as a novel functional adaptation of cortical epithelial cells for T cell selection. PMID: 27503071
    3. results show that CD83 is important for B cell activation and modulates germinal center composition and IgE Ab responses in vivo PMID: 26983787
    4. Our findings indicate that CD83 homotypic interactions regulate DC activation and promote mucosal homeostasis. PMID: 25204675
    5. CD83(+) T cells share important features with regulatory T cells, identifying CD83 as a novel lineage marker to discriminate between different T cell populations. PMID: 25151500
    6. CD83 differentially modulates follicular and marginal zone B cell responses PMID: 23728778
    7. Dendritic cells co-cultivated with antigen-specific induced Tregs expressed lower levels of CD83. A major suppressive mechanism of DC function by iTregs is secondary to the effects of IL-10 on MARCH1 & CD83 expression. PMID: 24218453
    8. activated T cells induce CD83 on B cells via CD40 engagement but independent of TCR/MHC binding and thus independent of antigen-specificity of B cells. PMID: 21277328
    9. found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1 PMID: 21220452
    10. Data strongly suggest that CD83 is expressed by B cells upon activation and contributes to the regulation of B cell function. PMID: 17710154
    11. Soluble CD83-Ig fusion protein is immunosuppressive, costimulatory when coimmobilized with anti-CD3, and by interacting with its ligand(s) is involved in regulation of immune response to tumor. PMID: 11884422
    12. CD83 expression influences CD4+ T cell development in the thymus. PMID: 11955430
    13. the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83. PMID: 12072358
    14. murine CD83 is expressed mainly on mature dendritic cells and on activated T cells PMID: 12687354
    15. M2 cells expressing CD83 can induce a tumor-destructive immune response also against SW1 cells and that this response can be made more effective by combining them with M2 cells expressing anti-CD137 scFv PMID: 15051893
    16. analysis of monomeric and dimeric isoforms of CD83 PMID: 15721284
    17. thymic selection in the presence of CD83-immunoglobulin leads to an intrinsic T cell defect of CD4-positive T cells resembling the phenotype described for CD4-positive T cells derived from CD83-deficient mouse strains PMID: 16841299
    18. CD83 is expressed on murine B cells upon activation and is involved in the regulation of humoral responses. PMID: 17266176
    19. Expression on T cells and dendritic cells modulates the immune response by activating dendritic cells and by delivering costimulatory signals for the stimulation of T cells. PMID: 17301951
    20. These studies further emphasize a role for CD83 in lymphocyte development and immune regulation and reveal an unexpected role for CD83 expression in influencing cell-surface MHC class II turnover. PMID: 17804692
    21. CD83 is a functionally significant and sensitive marker of early lymphocyte activation in vivo PMID: 17878352
    22. CD83 expression can contribute to the immunosuppressive function of CD4(+) T cells in vivo. PMID: 18424708
    23. CD83 expression levels did not significantly affect the capacity of the APC to activate CD8(+) or T cellsCD4(+) T cell activation PMID: 18675848
    24. provide much needed clarification of the true nature of CD83 promoter activity PMID: 18701714
    25. CD83 serves as a substrate of gene related to anergy in lymphocytes (GRAIL) protein and plays a role in CD4 T cell activation. PMID: 19542455

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Abundantly expressed in spleen and brain, but is also detected in most tissues analyzed.
  • 数据库链接：

    KEGG: mmu:12522

    STRING: 10090.ENSMUSP00000015540

    UniGene: Mm.57175