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  4. Recombinant Mouse CD27 antigen (Cd27)

Recombinant Mouse CD27 antigen (Cd27)

  • 中文名称：
    Recombinant Mouse CD27 antigen(Cd27)
  • 货号：
    CSB-CF004910MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd27; Tnfrsf7; CD27 antigen; CD27L receptor; T-cell activation antigen CD27; Tumor necrosis factor receptor superfamily member 7; CD antigen CD27
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-250
  • 氨基酸序列
    PNSCPDKHYWTGGGLCCRMCEPGTFFVKDCEQDRTAAQCDPCIPGTSFSPDYHTRPHCESCRHCNSGFLIRNCTVTANAECSCSKNWQCRDQECTECDPPLNPALTRQPSETPSPQPPPTHLPHGTEKPSWPLHRQLPNSTVYSQRSSHRPLCSSDCIRIFVTFSSMFLIFVLGAILFFHQRRNHGPNEDRQAVPEEPCPYSCPREEEGSAIPIQEDYRKPEPAFYP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
  • 基因功能参考文献：
    1. CD27 expression is upregulated in a subset of hematopoietic cluster cells, and CD27 marks hematopoietic stem cells (HSC), type II pre-HSCs, and progenitors with lymphoid potential within the cluster cells. PMID: 28588017
    2. CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies. PMID: 28495792
    3. CD27-dependent CD8(+) T cell priming and differentiation are shaped by the efficiency of NK responses to virus infection. PMID: 27798162
    4. HSCs appear to maintain expression of CD27 after hematopoietic injury when Kit expression is downregulated. PMID: 25892186
    5. Mature CD27low NK cells promote allograft survival under costimulatory blockade conditions by regulating alloreactive memory CD8+ T-cell responses in T-bet dependent manner. PMID: 25606781
    6. identify an IL-17-dependent lymphoid/myeloid cross-talk involving CD27(-) gammadelta T cells and small peritoneal macrophages that promotes ovarian tumor cell growth and thus counteracts cancer immunosurveillance PMID: 25114209
    7. memory CD8 T cells, generated through priming with CD27 agonists, proliferated more extensively than did 4-1BB-generated memory cells, but these cells failed to persist. PMID: 24860188
    8. the central role played by CD27/70 during secondary CD8(+) T-cell activation to a peptide Ag, and identify sCD70 as an immunotherapeutic adjuvant for antitumor immunity. PMID: 24002868
    9. under conditions of constitutive CD70 expression reflecting chronic immune activation, the CD27/CD70 system inhibits OC differentiation and favors DC differentiation PMID: 23832783
    10. mTECs and DCs form dedicated niches in the thymic medulla, in which CD27-CD70 co-stimulation rescues developing Treg cells from apoptosis, subsequent to Foxp3 induction by TCR and CD28 signals. PMID: 23547099
    11. The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity. PMID: 23159439
    12. population of CD27(-) Th2 cells was significantly reduced by the anti-CD70 mAb treatment PMID: 22499851
    13. The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27-CD70 interactions. PMID: 22781761
    14. These data indicate that CD27/OX40 can serve the central function as signal 3 mediators, independent of IFN or IL-12, for the generation of CD8(+) T cell immune memory. PMID: 22178730
    15. Data show that in a mouse model of chronic myelogenous leukemia, BCR/ABL+ leukemia stem and progenitor cells express CD27, and reveal a mechanism by which adaptive immunity contributes to leukemia progression. PMID: 22232214
    16. CD27 is dispensable for the development of functional NK cells. However, upon stimulation of NK cells, CD27 displays an important role in their activation and functionality. PMID: 21283110
    17. maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants PMID: 21763160
    18. Our findings suggest that antigen persistence may determine the opposing effects of CD27/CD70 signaling on CD8 T cell responses during acute and chronic lymphocytic choriomeningitis virus infection of mice. PMID: 21507976
    19. In this review, The CD27/CD70 axis has some unique properties that confer to it a crucial role as a regulator of immunity versus tolerance, favoring lymphocyte activation and survival and regulating immunity versus tolerance. PMID: 20699361
    20. CD27 costimulation is not critical for the development of asthma in an experimental disease model PMID: 20600327
    21. With strongly replicating (i.e., virulent) vaccinia virus, the TNFR family costimulatory receptors OX40 and CD27 were engaged and promoted the generation of high numbers of memory CD8+ T cells, which protected against a lethal virus challenge. PMID: 21183789
    22. The PIQED region of the CD27 tail is involved in inhibition of terminal differentiation of B cells. PMID: 20974987
    23. CD27 signaling upregulates antiapoptotic Bcl-2 family member Bcl-xL and supports generation of the CD8+ effector T cell pool, not only by counteracting apoptosis via Bcl-2 family members but also by directing expression of the Pim1 gene. PMID: 21048108
    24. CD27 signals are required for the expansion of interferon-gamma-producing gammadelta27-positive cells. PMID: 21037088
    25. LFA-1 signal defect-induced CD8(+) T cell apoptosis is associated with reduced CD27 costimulation and IL-15R survival signal, elucidating the molecular mechanism associated with LFA-1 signaling in effector and memory CD8(+) T cell survival PMID: 20569988
    26. Continuous CD70-CD27 interaction resulted in strongly down-modulated CD27 expression on NK cells and gradually reduced absolute NK cell numbers. PMID: 20140903
    27. CD27 signaling directs the IL-2 production that is reportedly essential to sustain survival of virus-specific CTLs in nonlymphoid tissue. PMID: 19955658
    28. Data show that the short lifespan of T(H)17 cells was associated with small amounts of the antiapoptotic protein Bcl-2, the IL-15 receptor and the receptor CD27. PMID: 19935657
    29. persistent delivery of costimulatory signals via CD27-CD70 interactions, as may occur during chronic active viral infections, can exhaust the T cell pool and is sufficient to induce lethal immunodeficiency PMID: 12469117
    30. Signaling through CD27 during B cell priming inhibits primary antibody responses and induces differentiation into the memory lineage. PMID: 14634097
    31. In addition to increasing the frequency of primed antigen-specific T cells, CD27 signaling during the primary response instills a program of differentiation that allows CD8+ T cells to overcome a state of unresponsiveness. PMID: 15128787
    32. Stimulation of CD27 on B cells by CD28(+) Th cells accelerates germinal center formation, most likely by promoting centroblast expansion. In addition, CD27 on T cells can partially substitute for CD28 in supporting GC formation. PMID: 15187121
    33. The novel costimulatory CD27-CD70 pathway is critical for CD28-independent effector/memory CD8+ alloreactive T cell activation in vivo. PMID: 15661893
    34. Hematopoiesis is modulated by immune activation through interactions between CD27 and CD70. PMID: 15723067
    35. Triggering of the costimulatory TNF receptor family member CD27 sensitizes T cells for CD95-induced apoptosis. PMID: 15879081
    36. During influenza A virus infection, formation of the same CD8+ memory T cell pool as well as its capacity for secondary expansion depend on the complementary contributions of CD27, 4-1BB, and OX40. PMID: 16034107
    37. purinergic receptor P2X stimulation by extracellular ATP results in rapid CD27 shedding via protease activation PMID: 16207496
    38. Ligation of CD27 on memory cytotoxic T lymphocytes upon secondary antigen encounter increases clonal expansion and improves protection against re-infection with lymphocytic choriomeningitis virus. PMID: 16231287
    39. CD27 is a key marker of the natural (NK) cell lineage, dividing the mature Mac-1high NK cell pool into two functionally distinct subsets. PMID: 16424180
    40. Data show that during lymphocytic choriomeningitis virus infection, CD27 signaling on CD4+ T cells enhances the secretion of interferon-gamma and tumor necrosis factor-alpha. PMID: 16923852
    41. CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation. PMID: 17159138
    42. accumulation of mature CD27(low) CD4 T cells in the lungs correlates with the degree of protection against infection PMID: 17202360
    43. Although CD27 is present on influenza virus-specific memory CD8-positive T cells, it is not required for the expansion of properly formed memory cells. PMID: 18292513
    44. regulating CD27 expression on memory CTL is a novel mechanism how CD4+ T cells control CTL memory PMID: 18506879
    45. CD27 instills specific functional activities into primed CD4+ T cells; functional impact of CD27 on CD4+ T cells is important for their CD8+ T cell helper activity, to endow memory CD8+ T cells with potential to accumulate after secondary challenge PMID: 18606659
    46. A 4-stage model of NK-cell maturation CD11b(low)CD27(low) --> CD11b(low)CD27(high) --> CD11b(high)CD27(high) --> CD11b(high)CD27(low). PMID: 19234143
    47. CD27 functions as a regulator of the differentiation of gammadelta T cells at least in part by inducing expression of the lymphotoxin-beta receptor and genes associated with trans-conditioning and interferon-gamma production. PMID: 19270712
    48. CD27/CD70 interactions at the T-cell/DC interface prime CD8(+) T cells to become tumor-eradicating cytolytic effectors and memory cells PMID: 19279334
    49. The CD27-CD70 costimulatory pathway plays a vital role in sustaining CD4+ T-cell mediated inflammation in colitis; blockade of the pathway leads directly to reduction in T cell numbers, less mucosal inflammation and fewer proinflammatory cytokines. PMID: 19525396
    50. the CD70- and CD27-driven costimulatory axis may be involved in shutdown of B cell responses before clearance of Ag PMID: 19864607

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    In thymus and spleen, but not in non-lymphoid tissues.
  • 数据库链接：

    KEGG: mmu:21940

    STRING: 10090.ENSMUSP00000032486

    UniGene: Mm.367714