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  4. Recombinant Mouse 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (Agpat3)

Recombinant Mouse 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (Agpat3)

  • 中文名称：
    Recombinant Mouse 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma(Agpat3)
  • 货号：
    CSB-CF861543MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Agpat3; Lpaat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; 1-acylglycerol-3-phosphate O-acyltransferase 3; 1-AGP acyltransferase 3; 1-AGPAT 3; Lysophosphatidic acid acyltransferase gamma; LPAAT-gamma
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-376
  • 氨基酸序列
    MGLLAYLKTQFVVHLLIGFVFVVSGLIINFTQLCTLALWPISKHLYRRINCRLAYSLWSQ LVMLLEWWSCTECTLFTDQATVDHFGKEHVVVILNHNFEIDFLCGWTMCERFGVLGSSKV LAKRELLCVPLIGWTWYFLEIVFCKRKWEEDRDTVIEGLRRLADYPEYMWFLLYCEGTRF TETKHRISMEVAASKGLPPLKYHLLPRTKGFTTAVQCLRGTVAAIYDVTLNFRGNKNPSL LGILYGKKYEADMCVRRFPLEDIPADETSAAQWLHKLYQEKDALQEMYKQKGVFPGEQFK PARRPWTLLNFLCWATILLSPLFSFVLGVFASGSPLLILTFLGFVGAASFGVRRLIGVTE IEKGSSYGNQELKKKE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol.
  • 基因功能参考文献：
    1. Data suggest that LPAAT3 is required for producing docosahexaenoic acid- (DHA)-containing phospholipids in various tissues, such as the testes and retina; LPAAT3-knockout mice exhibit severe male infertility with abnormal sperm morphology; lack of LPAAT3 causes drastic reduction of DHA-containing phospholipids in spermatids with excess cytoplasm around the sperm head. PMID: 28578315
    2. Data suggest that PL-DHA (docosahexaenoic acid-containing phospholipids) contribute to visual function by maintaining disc shape in photoreceptor cells; PL-DHA disappears from outer segment in LPAAT3-knockout mice; LPAAT3-knockout mice exhibit abnormalities in retinal layers, disordered disc morphology in photoreceptor cells, and impaired visual function. PMID: 28578316
    3. The induction of LPAAT3 during germ cell development critically contributes to the accumulation of PUFAs in testicular phospholipids, thereby possibly affecting sperm cell production. PMID: 21968070
    4. mAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption PMID: 16150824
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.
  • 蛋白家族：
    1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • 组织特异性：
    Widely expressed. Mainly expressed in testis, kidney and liver (at protein level).
  • 数据库链接：

    KEGG: mmu:28169

    STRING: 10090.ENSMUSP00000001240

    UniGene: Mm.141230