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Recombinant Mechanosensory protein 2 (mec-2)

  • 中文名称：
    秀丽隐杆线虫mec-2重组蛋白
  • 货号：
    CSB-CF631665CXY
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    mec-2
  • Uniprot No.：
  • 别名：
    mec-2; F14D12.4; Mechanosensory protein 2
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-481
  • 氨基酸序列
    MSATMSSARNSVVSLSSNGSVKVETRLVSNERSSSIQQEGAMLPSSSSKDDDLLSTSSDE VENMATRTLQQLEESTSIISANSDDDSVKKEKQAEKDVEKGNGKEEKANIQNEFGVCGWI LTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDTYRK VDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTTLRN ILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAEAEA AREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPI DLLSAFLQRTPPKVEEPPSLPKKIRSCCLYKYPDWVQGMVGSEGGGGHGHSHGGGGGGLG SSQGAFHPSQAGSGPSTTTTSGRPLLRSMREAQFHSAAPPISAPNQSQTSVSQLDPALLI R
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Subunit of an amiloride-sensitive cation channel (degenerin channel complex) permeable for sodium, potassium, lithium and N-methylglucamine, and required for mechanosensory transduction (touch sensitivity). Positively regulates the activity of the putative mechanosensory transduction channel. May link the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Required for the function of a set of six touch receptor neurons.
  • 基因功能参考文献：
    1. the carboxyl terminus of podocin/MEC-2 has to be placed at the inner leaflet of the plasma membrane to mediate cholesterol binding and contribute to ion channel activity. PMID: 24596097
    2. [review] Similarly to stomatins from other species, C. elegans counterparts may also be membrane proteins with intracellular amino- and carboxyl-terminals. PMID: 21501885
    3. MEC-2, Podocin, and probably many other PHB-domain proteins by binding to themselves, cholesterol, and target proteins regulate the formation and function of large protein-cholesterol supercomplexes in the plasma membrane PMID: 17079490
    4. MEC-2 with MEC-6 increase open probability of ENaC (constitutively active MEC-4/MEC-10 in Xenopus oocytes), decrease the efficiency of Ca2+ block. Its palmitoylation and cholesterol-binding activity are required for channel activation PMID: 18504316
  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    Band 7/mec-2 family
  • 数据库链接：

    KEGG: cel:CELE_F14D12.4

    STRING: 6239.F14D12.4a

    UniGene: Cel.7750