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  4. Recombinant Human respiratory syncytial virus B Major surface glycoprotein G (G)

Recombinant Human respiratory syncytial virus B Major surface glycoprotein G (G)

  • 中文名称：
    Recombinant Human respiratory syncytial virus B Major surface glycoprotein G(G)
  • 货号：
    CSB-CF523613HXK
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    G
  • Uniprot No.：
  • 别名：
    G; Major surface glycoprotein G; Attachment glycoprotein G; Membrane-bound glycoprotein; mG
  • 种属：
    Human respiratory syncytial virus B (strain B1)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-299
  • 氨基酸序列
    MSKHKNQRTARTLEKTWDTLNHLIVISSCLYRLNLKSIAQIALSVLAMIISTSLIIAAII FIISANHKVTLTTVTVQTIKNHTEKNITTYLTQVPPERVSSSKQPTTTSPIHTNSATTSP NTKSETHHTTAQTKGRTTTSTQTNKPSTKPRLKNPPKKPKDDYHFEVFNFVPCSICGNNQ LCKSICKTIPSNKPKKKPTIKPTNKPTTKTTNKRDPKTPAKTTKKETTTNPTKKPTLTTT ERDTSTSQSTVLDTTTLEHTIQQQSLHSTTPENTPNSTQTPTASEPSTSNSTQNTQSHA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities.; Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
  • 基因功能参考文献：
    1. Overall, human respiratory syncytial virus expressing the F of virus strain 2-20 had a high dependence on G for binding, entry, and infection. PMID: 26468535
    2. Positive selection was identified in the G-protein of subtypes A and B, but RSV-A's rate of evolution was slower than that of RSV-B,in South Africa 199-2012. PMID: 24265482
    3. secreted G protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement PMID: 22837211
    4. investigation of genetic variability of RSV-A circulating in Ontario; the 23 amino acid ON1 G gene duplication results in a repeat of 7 potential O-glycosylation sites including three O-linked sugar acceptors at residues 270, 275, and 283 PMID: 22470426
    5. Intrapatient variability of the attachment (G) protein gene of was examined using both population and single-genome sequencing. Samples from three patients infected with a group B virus variant had a 60-nucleotide duplication in the G protein gene. PMID: 20660195
    6. induces interleukin 1alpha, CC, and CXC chemokine responses in normal human bronchoepithelial cells PMID: 20205592
    7. this study confirms the prescenc of the 60 nucleotide duplication in the the glycoprotein G gene in human RSV type B strains in Australia PMID: 18752134

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  • 亚细胞定位：
    [Isoform Membrane-bound glycoprotein G]: Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein.; [Isoform Secreted glycoprotein G]: Secreted.
  • 蛋白家族：
    Pneumoviruses glycoprotein G family
  • 数据库链接：

    KEGG: vg:1489824