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  4. Recombinant Human Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1)

Recombinant Human Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1)

  • 中文名称：
    人VKORC1L1重组蛋白
  • 货号：
    CSB-CF818673HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    VKORC1L1
  • Uniprot No.：
  • 别名：
    VKORC1L1; Vitamin K epoxide reductase complex subunit 1-like protein 1; VKORC1-like protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-176
  • 氨基酸序列
    MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSA ALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALILMTSSIMS VVGSLYLAYILYFVLKEFCIICIVTYVLNFLLLIINYKRLVYLNEAWKRQLQPKQD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
  • 基因功能参考文献：
    1. This study showed that polymorphisms of EPHX1 and VKORC1L1 could be determinants of stable warfarin doses. PMID: 29054760
    2. a concerted action of the four conserved cysteines of VKORC1L1 for active site regeneration PMID: 24532791
    3. VKORC1L1 is responsible for driving vitamin K-mediated intracellular antioxidation pathways critical to cell survival. PMID: 21367861
    4. VKORC1L1 does not affect the variability of warfarin dose requirement in a Japanese patient population PMID: 17996924
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    VKOR family
  • 数据库链接：

    HGNC: 21492

    OMIM: 608838

    KEGG: hsa:154807

    STRING: 9606.ENSP00000353998

    UniGene: Hs.427232