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  4. Recombinant Human Prostaglandin D2 receptor (PTGDR)

Recombinant Human Prostaglandin D2 receptor (PTGDR)

  • 中文名称：
    人PTGDR重组蛋白
  • 货号：
    CSB-CF621658HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    PTGDR
  • Uniprot No.：
  • 别名：
    PTGDR; Prostaglandin D2 receptor; PGD receptor; PGD2 receptor; Prostanoid DP receptor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-359
  • 氨基酸序列
    MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR.
  • 基因功能参考文献：
    1. PGD2 signaling through the D-prostanoid receptor 1 (DP1) receptor is necessary for optimal microglia/macrophage activation and IFN expression after infection with a neurotropic coronavirus PMID: 28630327
    2. Polymorphisms of prostaglandin D receptor (PTGDR) gene influence basal promoter activity and gene expression, as well as the cytokine secretory pattern. PMID: 29088248
    3. An association was found between single nucleotide polymorphisms of the PTGFR and SLCO2A1 genes and the response to latanoprost in Han Chinese patients with glaucoma. These SNPs may be important determinants of differential response to latanoprost. PMID: 27336732
    4. EP2 receptors seem to be able to distinguish endogenous ligands PGD2, PGE2 or prostaglandin F2alpha better than DP receptors. PMID: 27636113
    5. PGD2 markedly augments disease activity through its ability to enhance the proinflammatory actions of macrophages and subsequent neutrophil activation. PMID: 26792210
    6. Non-obligatory role of prostaglandin D2 receptor subtype 1 in rosacea: laropiprant in comparison to a placebo did not alleviate the symptoms of erythematoelangiectaic rosacea PMID: 25142778
    7. EP2 receptors exhibit more constraints to mutations than DP receptors. PMID: 25681680
    8. Low DP1 prostanoid receptor is associated with gastric cancer progression. PMID: 24922638
    9. Lipocalin-type prostaglandin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the G protein-coupled receptor DP1 in an agonist-independent manner. PMID: 24493589
    10. the PTGDR -549 C/T polymorphism confers susceptibility to asthma in Europeans and adults. However, no association was found between the PTGDR 441 C/T and -197 C/T polymorphisms or the CCC and TCT haplotypes and asthma susceptibility. PMID: 23192614
    11. Genetic variant may play a role in NSAID induced acute urticaria. PMID: 23181793
    12. PGD(2)-DP signaling reduces vascular permeability via endothelial cAMP/PKA/Tiam1/Rac1 pathway. PMID: 23307871
    13. The PTGDR -441C/T polymorphism is not associated with asthma or its phenotypes in the North Indian population. PMID: 22182808
    14. DP receptors amplify the biological response to CRTH2 activation and the CRTH2/DP heteromer might represent both a functional signaling unit for PGD(2) and a potential target for development of heteromer-directed therapy for allergic diseases PMID: 21930295
    15. Genetic combinations described have functional implications in the PTGDR promoter activity by changing the transcription factors affinity that will help characterize different risk groups. PMID: 21883277
    16. PGD(2) can induce MUC5B overproduction via ERK MAPK/RSK1/CREB signaling and that DP1 receptor may have suppressive effects in controlling MUC5B overproduction in the airway. PMID: 21832046
    17. Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma. PMID: 21307858
    18. DP mediates eosinophils through the elevation of intracellular cAMP production but does not change CRTH2 expression; balance between DP and CRTH2 could influence the degree of PGD2-induced eosinophil migration PMID: 21624751
    19. during allergen-elicited eosinophilic inflammatory reactions, cysteinyl-leukotriene production is regulated by DP1/DP2-orchestrated eosinophil activation PMID: 20973774
    20. DP(1) receptors coupled to G(alphas) increase adenylate cyclase activity and cAMP/protein kinase A-dependent formation of lipid bodies, and DP(2) receptors coupled to G(alphai) increase calcium; each of these signals is required for LTC(4) production PMID: 21426314
    21. These results suggest that despite the non-significant findings in the present study populations, prostanoid D2 receptor promoter haplotypes may account for a small but significant proportion of the risk of asthma in Caucasian populations. PMID: 21199159
    22. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. PMID: 20308056
    23. Prostanoid DP receptor (PTGDR) polymorhisms variants was found in a subset of mothers with post-coital associated preterm births PMID: 19710676
    24. New polymorphisms of human prostanoid DP receptor gene. PMID: 12002745
    25. Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. PMID: 12230502
    26. amino acid sequence alignment of human, mouse and rat DP receptors PMID: 12895603
    27. Activation of the D prostanoid receptor DP1 impedes the TNF-alpha-induced migration of Langerhans cells (LC) from skin explants and strongly inhibits chemotactic responses of LC precursors and maturing LCs to CC chemokine ligands 20 and 19, respectively. PMID: 15004188
    28. Our functional and genetic findings identify PTGDR as an asthma-susceptibility gene. PMID: 15496624
    29. DP2 might play a critical role in allergic diseases PMID: 15749909
    30. activation of the prostanoid DP receptor on THP-1 cells enhances TNF-alpha-induced MCP-1 and IL-8 production via the cAMP/PKA signaling pathway PMID: 17307163
    31. study demonstrated significant evidence of association between polymorphisms in PTGDR with asthma phenotypes in two Caucasian populations PMID: 17538632
    32. Review. PGD(2) exerts its effects partly through the D-prostanoid receptor. The distribution of DP expression depends on the type of tissue and environment with/without inflammation. PMID: 17541272
    33. These results suggest that the three PTGDR gene promoter polymorphisms studied are not important risk factors for asthma susceptibility in the Chinese Han population. PMID: 17845306
    34. D-type prostanoid (DP) receptors comediate with CRTH2 the mobilization of eosinophils from bone marrow and their chemotaxis, which might provide the rationale for DP antagonists in the treatment of allergic disease PMID: 17878378
    35. activation of DP(1) may contribute to the long lasting blood flow changes in the target organ--REVIEW PMID: 17965752
    36. Expression of prostaglandin E(2) receptors (EP(2), EP(3), EP(4)), prostaglandin D(2) receptor (DP(2)), prostanoid thromboxane A(2) receptor (TP) and to a lesser extent EP(1) were observed in several hair follicle compartments. PMID: 18005048
    37. level of exptression in nasal polyps correlates with chronic rhinosinusitis associated with bronchial asthma PMID: 18797183
    38. These results suggest that expression of DP and CRTH2 is associated with the pathophysiology of chronic rhinosinusitis, and the expression of these receptors may be regulated by h-PGDS and PGD. PMID: 18802357
    39. promoter polymorphism association in Spanish children with asthma PMID: 18811623
    40. PGD(2) induces HO-1 mRNA expression through DP2 receptor, linking the PGD(2)-DP2 signaling with heme homeostasis. PMID: 18957281
    41. Our results do not support PTGDR to be a major candidate gene for asthma traits and atopy in Chinese children. PMID: 19220773

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  • 相关疾病：
    Asthma-related traits 1 (ASRT1)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.
  • 数据库链接：

    HGNC: 9591

    OMIM: 604687

    KEGG: hsa:5729

    STRING: 9606.ENSP00000303424

    UniGene: Hs.306831