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  4. Recombinant Human PRA1 family protein 3 (ARL6IP5)

Recombinant Human PRA1 family protein 3 (ARL6IP5)

  • 中文名称：
    Recombinant Human PRA1 family protein 3(ARL6IP5)
  • 货号：
    CSB-CF002096HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    ARL6IP5
  • Uniprot No.：
  • 别名：
    ARL6IP5; DERP11; JWA; PRA2; PRAF3; HSPC127; PRA1 family protein 3; ADP-ribosylation factor-like protein 6-interacting protein 5; ARL-6-interacting protein 5; Aip-5; Cytoskeleton-related vitamin A-responsive protein; Dermal papilla-derived protein 11; GTRAP3-18; Glutamate transporter EAAC1-interacting protein; JM5; Prenylated Rab acceptor protein 2; Protein JWa; Putative MAPK-activating protein PM27
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-188
  • 氨基酸序列
    MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISIVGF LSPFNMILGGIVVVLVFTGFVWAAHNKDVLRRMKKRYPTTFVMVVMLASYFLISMFGGVM VFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKRTPMGIVLDALEQQEEGINRLT DYISKVKE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.
  • 基因功能参考文献：
    1. These data demonstrated that JWA suppressed the migration/invasion of breast carcinoma cells by downregulating the expression of CXCR4, and suggested that JWA may harbor prognostic and therapeutic potential in patients with breast cancer. PMID: 29658570
    2. increased RNF185 expression facilitated GC cell migration in vitro and promoted GC metastasis in vivo by downregulating JWA expression. PMID: 29481911
    3. our results demonstrate that JWA is a novel negative regulator of HER2 expression...in HER2-positive gastric cancer cells PMID: 27167206
    4. Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK/PI3K-Nrf2 axis. PMID: 28428137
    5. JWA and topoisomerase II alpha regulate each other in tumor cells arrested in G2/M. PMID: 26046674
    6. the JWA gene may regulate human breast cancer cells through the MAPK signaling pathway using different types of regulation. PMID: 25586271
    7. This review gives an overview of EAAC1-mediated GSH synthesis, and its regulatory mechanisms by GTRAP3-18 in the brain, and a potential approach against neurodegeneration. PMID: 23109897
    8. JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells. PMID: 25476899
    9. data demonstrate that JWA plays a crucial role in HCC progression and suggest JWA may be a potential prognostic biomarker and therapeutic target for HCC. PMID: 23169062
    10. A significant negative correlation between JWA and ILK in melanoma biopsies. PMID: 24064223
    11. Loss of JWA expression was strongly correlated with increased gastric cancer angiogenesis. PMID: 24072772
    12. JWA has an important role in ING4-regulated melanoma angiogenesis, and ING4/JWA/ILK are promising prognostic markers and may be used as anti-angiogenic therapeutic targets for melanoma. PMID: 24157826
    13. A combined effect of p53 with JWA as efficient prognostic indicators was found for the first time. PMID: 23285001
    14. JWA plays an important role in the occurrence and progress of human esophageal squamous cell carcinoma (ESCC) and that high expression level of JWA may predict a favorable prognosis in ESCC patients. PMID: 23461062
    15. JWA and XRCC1 protein levels were downregulated in gastric cancer lesions compared with adjacent noncancerous tissues;JWA and XRCC1 protein expressions in tumor are candidate prognostic markers and predictive factors for benefit from adjuvant platinum-based chemotherapy in resectable gastric carcinoma PMID: 22452940
    16. The gene polymorphisms at site 76 and GG/CT haploid type of JWA gene were associated with hypertension in workers exposed to high temperature. PMID: 22357531
    17. PRAF3 plays an important role in the regulation of tumor progression and metastasis and serves as a tumor suppressor in human ESCC. We propose that PRAF3 might be used as a potential therapeutic agent for human ESCC. PMID: 22433565
    18. JWA night play an important role in neoplastic transformation of HBE cells through regulation of p53 expression. PMID: 19080375
    19. all-trans retinoic acid increased JWA gene expression in human pulmonary artery smooth muscle cells. PMID: 16638297
    20. Rsults suggest that JWA can be regulated by oxidative stress and is actively involved in the signal pathways of oxidative stress in the cells. PMID: 15864752
    21. Data show that the JWA -76G-->C variant genotype may play an important role in transcription regulation of JWA gene and in the susceptibility to bladder cancer. PMID: 16331563
    22. JWA may function as a lineage-restricted gene during differentiation along the monocyte/macrophage-like or granulocytic pathway PMID: 16430862
    23. all-trans retinoic acid up-regulates JWA expression by stimulating the transcriptional activity of JWA gene promoter PMID: 16468075
    24. The JWA determined might function as a potential effective environmental responsive gene and actively participated in the process of B (a) P exposure associated with intracellular signal pathways of DNA damage and repair PMID: 16640902
    25. JWA participates in the signal pathways of H2O2 induced oxidative stress in K562 cells PMID: 16766476
    26. The effects of All Trans Retinoic Acid in regulating cellular proliferation and apoptosis may be mediated in part by JWA expression. PMID: 16922813
    27. JWA regulated-tumor cellular migration might involve MAPK cascades activation and F-actin cytoskeleton rearrangement mechanisms. PMID: 17336041
    28. Three novel functional genetic poly- morphisms of JWA gene, -76C, 454A, and 723G, appear to contribute to the etiology of bladder cancer PMID: 17479401
    29. Single nucleotide polymorphisms of JWA were associated with enhanced risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population. PMID: 17479402
    30. The potentially functional genetic polymorphism 454CA of the JWA gene appears to contribute to the risk of multiple kinds of leukemia in a south Chinese population. PMID: 17479403
    31. These results show GTRAP3-18 to negatively and dominantly regulate cellular GSH content via interaction with EAAC1 at the plasma membrane. PMID: 17646425
    32. Expression of GTRAP3-18 delays the ER exit of EAAC1, as well as other members of the excitatory amino acid transporter family. PMID: 18167356
    33. This paper deals primarily with PRAF2, but comparisons with PRAF3 are also provided. PMID: 16481131
    34. protein expression is upregulated by methyl-beta-cyclodextrin and not by retinoic acid PMID: 12562531
    35. highly conserved protein and genomic organization amongst vertebrates PMID: 12119102

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    PRA1 family
  • 数据库链接：

    HGNC: 16937

    OMIM: 605709

    KEGG: hsa:10550

    STRING: 9606.ENSP00000273258

    UniGene: Hs.518060