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  4. Recombinant Human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NDUFA13)

Recombinant Human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NDUFA13)

  • 中文名称：
    人NDUFA13重组蛋白
  • 货号：
    CSB-CF889167HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    NDUFA13; GRIM19; CDA016; CGI-39; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Cell death regulatory protein GRIM-19; Complex I-B16.6; CI-B16.6; Gene associated with retinoic and interferon-induced mortality 19 protein; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-144
  • 氨基酸序列
    AASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRLQ IEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPLI GELYGLRTTEEALHASHGFMWYT
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
  • 基因功能参考文献：
    1. These results indicated that rAd-Grim-19 may regulate tumor cell growth and apoptosis. Additionally, the results demonstrated that rAdGrim19 led to beneficial outcomes and prolonged the survival of esophageal tumorbearing mice. In conclusion, the present study demonstrated that rAdGrim19 may have potential as an antitumor agent for esophageal neoplasms PMID: 29488605
    2. Low GRIM19 expression is associated with radiation resistance in osteosarcoma. PMID: 30005830
    3. GRIM-19 is a potential predictor of prognosis and disease recurrence in high grade serous carcinoma PMID: 29254797
    4. Promoting the expression of GRIM19 may yield therapeutic benefits in the treatment of RA. PMID: 29306209
    5. MiR-6743-5p may act as an oncomiRNA in glioma by targetting GRIM-19 and STAT3. PMID: 29074558
    6. GRIM-19 suppresses the proliferation and invasion of cutaneous squamous cell carcinoma cells associated with downregulation of STAT3 signaling. PMID: 28926927
    7. Mitochondrial GRIM-19 could not only serve as an valuable prognostic biomarker for gastric cancer development, but also as a potential therapeutic target for STAT3-dependent carcinogenesis of Gastric cancer. PMID: 27167343
    8. GRIM-19 expression in cervical cancer cells could inhibit telomerase activity by inhibiting the transactivation of the hTERT promoter by E6, thereby promoting cervical cancer cell senescence. PMID: 27142689
    9. NDUFA13 deficiency may be associated with asthenozoospermia through the disturbance of spermatozoa mitochondrial membrane potential and by increasing apoptosis and intracellular reactive oxygen species PMID: 27789183
    10. GRIM-19 overexpression suppressed hepatocellular carcinoma (HCC) growth and downregulated AKT1 expression, suggesting that GRIM-19 might play a crucial role in hepatocarcinogenesis through negatively regulating the PI3K/AKT signaling pathway. PMID: 25550785
    11. Low GRIM-19 expression is associated with paclitaxel resistance in cervical cancer. PMID: 26810068
    12. activation of AMPKalpha by metformin was associated with a reversal of the suppressed GRIM-19 expression in H9C2 cells, the fold of changes in GRIM-19 expression by metformin were much less in HeLa cells PMID: 27101310
    13. Data suggest that tumor expression of Ki67 (antigen Ki-67) and GRIM19 correlate with malignancy in thyroid Hurthle cell (HC) tumors; variable expression of Ki67 and GRIM19 may helped differentiate HC carcinoma from HC adenoma. PMID: 26188382
    14. Transfection with eukaryotic plasmid for the simultaneous expression of GRIM19 and LKB1 more effectively suppressed the growth of breast cancer in vitro and in vivo, and may therefore have therapeutic potential for the treatment of human breast cancer. PMID: 26458553
    15. Aberrant endometrial expression of GRIM-19 was associated with adenomyosis through the regulation of apoptosis and angiogenesis. PMID: 26769301
    16. We established here a correlation between the first mutation identified in the NDUFA13 gene, which induces Mitochondrial complex I instability and a severe but slowly evolving clinical presentation affecting the central nervous system. PMID: 25901006
    17. Upregulation of GRIM-19 also suppressed the secretion of urokinase-type plasminogen activator (u-PA), matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor (VEGF). PMID: 25955394
    18. GRIM-19 expression is closely associated with colorectal cancer progression and might be a very promising prognostic biomarker PMID: 26363526
    19. Upregulation of GRIM-19 in oral squamous cell carcinoma cells significantly inhibited cell proliferation, migration and invasion in vitro and suppressed tumor growth in vivo. PMID: 25174621
    20. decreased GRIM-19 expression due to promoter hypermethylation may be important in head and neck carcinogenesis by promoting cell proliferation and regulating metabolic activity PMID: 25575809
    21. Simultaneous expression of ADAM10-specific siRNA and GRIM19 in HepG2 cancer cells significantly inhibited the proliferation, migration and invasion. PMID: 25242535
    22. The GRIM-19 deficiency in the villus may be associated with missed abortion via increasing apoptosis and affecting angiogenesis. PMID: 25455534
    23. GRIM-19 may regulate the differentiation of normal cervical tissue, and a decrease in GRIM-19 may be the result of HR-HPV infection, which in turn leads to the malignant transformation of the cells. PMID: 24690422
    24. GRIM-19 mutations are associated with oral squamous cell carcinoma. PMID: 23851499
    25. role in macrophage apoptosis induced by H5N1 virus PMID: 23529854
    26. silencing of survivin and over-expression of GRIM-19 can significantly inhibit the growth and induce the apoptosis of Hep-2 laryngeal cancer cells in vitro and in vivo. PMID: 24133585
    27. Downregulation of GRIM-19 promotes HIF1alpha synthesis. PMID: 23580587
    28. Expressions of GRIM-19, NDUFS3, and extracellular matrix elements are correlated with invasive capabilities of breast cancer cell lines. PMID: 23630608
    29. Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast carcinomas. PMID: 23618357
    30. GRIM-19 expression is closely correlated with histological grading and p-STAT3 in hepatocellular carcinoma PMID: 22492280
    31. Our study found that GRIM-19 expression in lung cancer exhibits a relationship with the histological type and clinical stage PMID: 22573109
    32. Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis PMID: 23386605
    33. import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain PMID: 23271731
    34. GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation. PMID: 23124042
    35. GRIM-19 plays a critical role not only at the origin but also in the invasive progression of hepatocellular carcinoma. PMID: 22105514
    36. GRIM-19 expression was lower in gliomas & negatively correlated with malignancy. Downregulation enhanced cell proliferation & migration, but overexpression did the opposite. GRIM-19 exerts its role through the non-STAT3 signaling pathway. PMID: 21827581
    37. GRIM-19 function in cancer development PMID: 21664299
    38. The expressions of survivin and GRIM-19 may be closely correlated with the pathogenesis of prostate cancer. PMID: 21351527
    39. These data suggest that GRIM-19 can block E6/E6AP complex; and synergistically suppress cervical tumor growth with p53. PMID: 21765936
    40. reduced mRNA and protein levels in lung adenocarcinoma tissues PMID: 21040996
    41. GRIM-19 expression is down-regulated in non-small cell lung cancer. PMID: 19622307
    42. Results identify a major role for the N terminus of GRIM-19 in mediating its tumor-suppressive actions. PMID: 20595633
    43. Alternatively spliced GRIM-19 mRNA is associated with kidney cancer. PMID: 20505682
    44. GRIM-19/CDKN2A synergistically suppressed cell cycle progression via inhibiting E2F1-driven gene expression. PMID: 20522552
    45. Loss of GRIM-19 is associated with invasion and metastasis of human gastric cancer. PMID: 20478305
    46. Data show that restoration of GRIM-19 levels reestablishes the control over STAT3-dependent gene expression and tumor growth in vivo. PMID: 19642906
    47. results collectively indicate that viral interferon regulatory factor 1 modulates interferon/retinoic acid-cell death signals via interactions with GRIM19 PMID: 12163600
    48. GRIM-19 is an inhibitor of signal transducer and activator of transcription 3 PMID: 12867595
    49. GRIM-19 may be a key component in NOD2-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes PMID: 15753091
    50. The IFN-beta- and tretinoin-induced GRIM-19 is upregulated during focal cerebral ischemia. PMID: 17523870

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  • 相关疾病：
    Hurthle cell thyroid carcinoma (HCTC)
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus.
  • 蛋白家族：
    Complex I NDUFA13 subunit family
  • 组织特异性：
    Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
  • 数据库链接：

    HGNC: 17194

    OMIM: 607464

    KEGG: hsa:51079

    STRING: 9606.ENSP00000423673

    UniGene: Hs.534453