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  4. Recombinant Human Leucine-rich repeat-containing protein 3B (LRRC3B)

Recombinant Human Leucine-rich repeat-containing protein 3B (LRRC3B)

  • 中文名称：
    人LRRC3B重组蛋白
  • 货号：
    CSB-CF857000HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    LRRC3B
  • Uniprot No.：
  • 别名：
    LRRC3B; LRP15; UNQ195/PRO221; Leucine-rich repeat-containing protein 3B; Leucine-rich repeat protein 15
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    34-259
  • 氨基酸序列
    CPKGCLCSSSGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVL NLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVHKNAFNNLKARARIANNPWHCDCTL QQVLRSMASNHETAHNVICKTSVLDEHAGRPFLNAANDADLCNLPKKTTDYAMLVTMFGW FTMVISYVVYYVRQNQEDARRHLEYLKSLPSRQKKADEPDDISTVV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. The expression of LRRC3B is downregulated in non-small cell lung cancer compared with normal epithelial cells. PMID: 27118644
    2. LRRC3B may serve as an important tumor suppressor in non-small-cell lung cancer PMID: 26276358
    3. LRRC3B gene expression and promoter hypermethylation in breast carcinomas PMID: 24839112
    4. Data suggest that LRRC3B gene could be involved in the process of carcinogenesis as a tumor suppressor gene. PMID: 22321817
    5. The LRRC3B gene promoter was methylated in 43% of clear cell renal carcinoma samples. PMID: 22101383
    6. The expression of LRP15 is controlled by methylation in its promoter in HeLa cells, and LRP15 confers resistance to ultraviolet rays damage and accelerates the DNA repair rate. PMID: 18377727
    7. suggest that LRRC3B is a putative tumor suppressor gene that is silenced in gastric cancers by epigenetic mechanisms and that LRRC3B silencing in cancer may play an important role in tumor escape from immune surveillance PMID: 18757430
    8. LRRC3B may be a novel methylation-sensitive tumor suppressor gene in CRC. LRRC3B methylation has significant tumor specificity and may be a biomarker of CRC. PMID: 18815942

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  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    LRRC3 family
  • 数据库链接：

    HGNC: 28105

    KEGG: hsa:116135

    STRING: 9606.ENSP00000379880

    UniGene: Hs.517868