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  4. Recombinant Human Cardiolipin synthase (CRLS1)

Recombinant Human Cardiolipin synthase (CRLS1)

  • 中文名称：
    Recombinant Human Cardiolipin synthase(CRLS1)
  • 货号：
    CSB-CF890725HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    CRLS1
  • Uniprot No.：
  • 别名：
    CRLS1; C20orf155; CLS1; Cardiolipin synthase; CMP-forming; CLS; Protein GCD10 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-301
  • 氨基酸序列
    MLALRVARGSWGALRGAAWAPGTRPSKRRACWALLPPVPCCLGCLAERWRLRPAALGLRL PGIGQRNHCSGAGKAAPRPAAGAGAAAEAPGGQWGPASTPSLYENPWTIPNMLSMTRIGL APVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNWANQRSALGSALDPLADKILISIL YVSLTYADLIPVPLTYMIISRDVMLIAAVFYVRYRTLPTPRTLAKYFNPCYATARLKPTF ISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCFTAFTTAASAYSYYHYGRKTVQVIK D
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
  • 基因功能参考文献：
    1. Knockdown of human CRLS1 leads to a cardiolipin decrease, phosphatidylglycerol accumulation and mitochondrial elongation. PMID: 29251771
    2. transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment. PMID: 22584571
    3. CLS mRNA levels cannot be correlated with CLS enzyme activity nor CL content in the LPS model of inflammation. PMID: 20652826
    4. A human candidate gene/cDNA for cardiolipin synthase, C20orf155, was identified. PMID: 16678169
    5. hCLS1 protein was localized to the mitochondria when transiently expressed in COS-7 cells PMID: 16716149
    6. We describe here a human gene for CLS and its analysis via RNAi knockdown on apoptotic progression. PMID: 16888643
    7. anti-cardiolipin antibody positivity is an independent predictor of chronic renal failure PMID: 19048414
    8. Patients with solid and non-solid malignancies display anticardiolipin antibodies associated with increased rate of thrombosis PMID: 19048416
    9. presence of cardiolipin autoantibodies is criteria for diagnostics of antiphospholipid syndrome PMID: 19052923
    10. associated with Libman-Sacks endocarditis, cardiac manifestation of SLE PMID: 19089657
    11. antibodies occur frequently in viral infections, particularly, in HIV but not in bacterial infections PMID: 19089659

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  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CDP-alcohol phosphatidyltransferase class-I family
  • 组织特异性：
    Highly expressed in tissues such as heart, skeletal muscle and liver.
  • 数据库链接：

    HGNC: 16148

    OMIM: 608188

    KEGG: hsa:54675

    STRING: 9606.ENSP00000368140

    UniGene: Hs.743956