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  4. Recombinant Human Bax inhibitor 1 (TMBIM6)

Recombinant Human Bax inhibitor 1 (TMBIM6)

  • 中文名称：
    人TMBIM6重组蛋白
  • 货号：
    CSB-CF023632HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    TMBIM6
  • Uniprot No.：
  • 别名：
    TMBIM6; BI1; TEGT; Bax inhibitor 1; BI-1; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-237
  • 氨基酸序列
    MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLS ALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMG TAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVV MCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation.
  • 基因功能参考文献：
    1. BI-1 is overexpressed and promotes the progression and metastasis of non-small cell lung cancer PMID: 25973025
    2. These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues PMID: 25764978
    3. Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger. PMID: 25227609
    4. BI-1 enhances glucose metabolism, leading to high activation of the sodium/hydrogen exchange for intracellular pH homeostasis. PMID: 24314142
    5. Results highlight the regulatory role of BI-1 in idiopathic pulmonary fibrosis. PMID: 24625972
    6. The effect of Bax Inhibitor-1(TMBIM6) as a regulatorof endoplasmic reticulum Ca2+ homeostasis is regulated by intracellular pH by removing negative charges. PMID: 23867001
    7. Constructed lentivirus expression vector for transfecting BI-1. PMID: 24344041
    8. Data indicate that GAAP and BI-1 have a six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop. PMID: 22418439
    9. The results reveal BI-1 as a novel autophagy regulator that bridges Ca(2) signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress. PMID: 22588718
    10. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. PMID: 22128171
    11. Lentivirus-mediated RNA interference targeting Bax inhibitor-1 suppresses ex vivo cell proliferation and in vivo tumor growth of nasopharyngeal carcinoma. PMID: 21545297
    12. highly maintained lysosomal activity may be one of the mechanisms by which BI-1 exerts its regulatory effects on the ER stress response and cell death. PMID: 21586565
    13. expression of BAX inhibitor-1 is associated with acidic pH-induced calcium release, cell death, and pro-inflammatory cytokine release in human osteoblasts PMID: 21601004
    14. Brain tissue from BI-1 transgenic mice shows reduced levels of apoptotic cells and reduced induction of markers of endoplasmic reticulum stress after brain injury. PMID: 21075086
    15. These findings suggest that BI-1 can lead cancer invasion and metastasis by inducing extracellular environment acidic. PMID: 21537843
    16. Studies indicate that manipulation of BI-1 has the potential for significant therapeutic benefit in a wide range of diseases. PMID: 21297665
    17. the pathway by which estrogen induces apoptosis is possibly through an up-regulation of Klf10 that decreases BI-1 and finally increases the concentration of cytoplasmic calcium PMID: 21262377
    18. post-translational regulation of the BI-1 protein by E3 ligase BAR contributes to the dynamic control of IRE1 signaling during endoplasmic reticulum stress PMID: 21068390
    19. BI-1 expression is down-regulated as liver damage progresses. PMID: 20359348
    20. Data show that BI-1 increased actin polymerization and cell adhesion through Ca2+ regulation and actin interaction. PMID: 20123969
    21. down-regulation of BI-1 lead to the activation of the associated cell death pathways PMID: 19579059
    22. Results indicate that the human Bax inhibitor-1 gene may serve as a prostate cancer expression marker based on its overexpression in prostate carcinoma and prostate cancer cell lines. PMID: 12875974
    23. BI-1 gene expression is conserved evolutionarily and may act as a key regulator of the apoptotic pathway in bronchiolalveolar carcinoma PMID: 16353209
    24. BI-1 can inhibit the endoplasmic reticulum stress proteins as well as the accumulation of Rreactive oxygen species, thereby protecting the cells. PMID: 17526500
    25. BI-1 and Bcl-X(L) operate downstream of or parallel to Bax/Bak PMID: 18299329
    26. BI-1 increases Ca(2+) leak rates from the ER through a mechanism that is dependent on pH and on the carboxyl-terminal cytosolic region of the BI-1 protein. PMID: 18378668
    27. The tmbim6 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments PMID: 18440869
    28. Results report the simultaneous refolding and reconstitution of the recombinant Bax inhibitor-1 (BI-1) from inclusion bodies expressed in Escherichia coli. PMID: 19284981
    29. These results suggest that reconstituted Bax inhibitor-1 has a Ca(2+)/H(+) antiporter-like activity. PMID: 19290886
    30. Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1. PMID: 19339548
    31. Bax inhibitor-1 overexpression in 3T3-L1 preadipocytes inhibits calcium mobilizing agent-induced suppression of adipogenesis. PMID: 19433315

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    BI1 family
  • 组织特异性：
    Highly abundant in testis.
  • 数据库链接：

    HGNC: 11723

    OMIM: 600748

    KEGG: hsa:7009

    STRING: 9606.ENSP00000389277

    UniGene: Hs.743965