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  4. Recombinant Human Aquaporin-9 (AQP9)

Recombinant Human Aquaporin-9 (AQP9)

  • 中文名称：
    Recombinant Human Aquaporin-9(AQP9)
  • 货号：
    CSB-CF001973HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    AQP9
  • Uniprot No.：
  • 别名：
    AQP9; SSC1; Aquaporin-9; AQP-9; Aquaglyceroporin-9; Small solute channel 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-295
  • 氨基酸序列
    MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines.
  • 基因功能参考文献：
    1. downregulation of AQP9 in cultured chondrocytes decreased the catabolic gene expression in response to IL1beta stimulation through nuclear factorkappaB signaling. PMID: 29901079
    2. AQP9 together with CLDN2 may have a role regulating tissue-specific physiological properties in tight junctions in UC. An additional functional role for AQP9 in the synthesis and/or the function of mucus can be implied. PMID: 29040430
    3. Data suggest that expression of aquaporin-9 in term placenta is up-regulated by leptin. These studies used placental explants following term birth via cesarean section. PMID: 28942694
    4. These findings showed that eclamptic seizures induced cell death and that upregulation of AQP4 and AQP9 may play an important role in this pathophysiological process. PMID: 29351212
    5. AQP9 transports two clinically important for anticancer therapy compounds, monomethyselenic acid and selenite. PMID: 28798983
    6. The identification of AQP9-induced tumor sensitivity to 5-Fluorouracil highlights the role of AQP9 in regulating chemosensitivity in colorectal cancer. PMID: 28640255
    7. AQP9 is down-regulated in hepatocellular carcinoma and its over-expression suppresses hepatoma cell invasion through inhibiting epithelial-to-mesenchymal transition. PMID: 27216981
    8. pH-dependent substrate permeability, measurements of media alkalization, and proton decoupling that AQP9 acts as a channel for the protonated, neutral monocarboxylic acid species. PMID: 28360107
    9. AQP9 is involved in the activation of the ERK pathway in androgen-independent prostate cancer cells. PMID: 27187384
    10. trophoblast from gestational diabetes express higher amount of aquaporin 9. PMID: 27082037
    11. AQP9 decreases in hepatocellular carcinoma. Dibutrylyl cAMP increases AQP9 levels, suppressing tumor growth. PMID: 27022216
    12. Our findings implicate the involvement of AQP9 in H2O2 transport in human and mice cells. PMID: 26837049
    13. we suggest that AQP9 is involved in viral tropism and pathogenesis of Herpes simplex encephalitis PMID: 25604497
    14. AQP9 downregulation together with the subsequent reduction in hepatic glycerol permeability in insulin-resistant states emerges as a compensatory mechanism whereby the liver counteracts further triacylglycerol accumulation PMID: 24418844
    15. AQP9 expressing glioma cells were negative for the brain tumor stem cell marker CD15. PMID: 24086629
    16. Placental expression of the arsenic transporter AQP9 was positively associated with maternal urinary arsenic levels during pregnancy. AQP9 expression related to phospholipase ENPP2 expression which was positively associated with infant birth weight. PMID: 23866971
    17. Reduced expression of AQP9 in human fallopian tube may contribute to aspects of pathophysiology of tubal ectopic pregnancy. PMID: 23238960
    18. AQP9, rather than other biomarkers such as cell surface markers and chromosomal alterations, correlate closely with the sensitivity to arsenic trioxide in acute promyelocytic leukemia cell lines. PMID: 23563754
    19. The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site. PMID: 23448163
    20. The interplay of water fluxes through AQP9 and actin dynamics regulate the cellular protrusive and motile activity of cells. PMID: 23573219
    21. AQP9 expression is lower in patients with stage III colorectal cancer who do not respond to adjuvant chemotherapy PMID: 23612070
    22. There is a coordinated regulation of adipose AQP7 and hepatic AQP9 gene expression that is distorted in metabolic syndrome X. (Review) PMID: 22425521
    23. Multi-tissue gene expression studies reveal SERPINA1 and AQP9 variants as genes for atherosclerosis. PMID: 22916037
    24. Using transcriptional signatures of blood samples,identified S100A11 as a potential diagnostic marker of infective endocarditis, and AQP9 as a potential prognostic factor. PMID: 22319637
    25. Aquaporin 9 is linked to the tumorigenesis of glioblastoma. PMID: 22262958
    26. The expression levels of aquaporin 9 were approximately 2 times higher in the chorion cells than those in the amnion cells following arsenite administration. PMID: 21945491
    27. AQP9 plays an active role in neutrophil volume regulation and migration PMID: 21873454
    28. Elevated serum levels of human chorionic gonadotrophin may be involved in increased aquaporin-9 protein expression in preeclamptic placenta explants via adenosine 3',5'-cyclic phosphate pathways. PMID: 20220109
    29. Genetic variation in the AQP9 gene is associated with femoral neck BMD in postmenopausal women, and may represent one of the susceptibility genes for phenotypes related to bone mass PMID: 20960106
    30. insulin treatment inhibited the expression of AQP9 in normal liver cells PMID: 20587318
    31. Hyperandrogenism in follicular fluid of women with polycystic ovary syndrome inhibited AQP-9 in granulosa cells through the PI3K pathway. PMID: 20378617
    32. The examination was performed whether aquaporin (AQP) 9 is expressed in normal skeletal muscle at mRNA and protein levels. PMID: 19629726
    33. The results suggest that in addition to the initial uptake of trivalent inorganic As(III) inside cells, AQP9 plays a dual role in the detoxification of arsenic metabolites by facilitating efflux from cells. PMID: 19802720
    34. AQP9 expression in fetal membranes was significantly higher in spontaneous term labor when compared with term-not in labor membranes. PMID: 19916714
    35. AQP9 can modulate drug sensitivity in cancer. PMID: 15336539
    36. The APQ9 mRNA expression in fetal membranes suggest that APQ9 may be an important water channel in intramembranous amniotic fluid water regulation. PMID: 15592307
    37. results provide new evidences that suggest the involvement of AQP9 and UT-A in the urea excretion mechanism across human term placenta from mother to fetus in physiological conditions PMID: 16480766
    38. We propose that increased water influx through AQP9 is critically involved in the formation of membrane protrusions, and that AQP9-induced actin polymerization is augmented by activation of Cdc42 and PKC(zeta). PMID: 17346701
    39. The expression of AQP9 in glioblastoma was studied. PMID: 17525633
    40. decreased hepatic AQP9 expression observed in obese T2DM subjects suggests a potential role in glycerol release from adipose tissue PMID: 18401671
    41. Results indicate that aquaporin-9 may play an important role in the malignant progression of brain astrocytic tumours. PMID: 18652774
    42. hAQP9 functions as a facilitative carrier for glycerol. PMID: 18762715
    43. The present study strongly suggests that membrane transporters responsible for arsenic uptake, such as AQP9, may play a critical role in development of arsenic resistance in human lung cancer cells. PMID: 19100828
    44. CFTR expression decreases in preeclampsia and may thus be implicated in the regulation of AQP9 activity PMID: 19481256
    45. we found a greater expression found in visceral fat, and between subcutaneous adipose aquaporin 7 and hepatic AQP9 gene expression within the context of human morbid obesity PMID: 19615702

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.
  • 数据库链接：

    HGNC: 643

    OMIM: 602914

    KEGG: hsa:366

    STRING: 9606.ENSP00000219919

    UniGene: Hs.104624