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Recombinant Human Aquaporin-7 (AQP7)

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  • 中文名称：
    Recombinant Human Aquaporin-7 (AQP7)
  • 货号：
    CSB-CF001967HU
  • 规格：
    ￥9720
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 别名：
    AQP-7;Aquaglyceroporin-7;Aquaporin adipose;AQPap;Aquaporin-7-like
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    38.6
  • 表达区域：
    1-342aa
  • 氨基酸序列
    MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney.
  • 基因功能参考文献：
    1. ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation PMID: 27832861
    2. a direct involvement of AQP7 in water and glycerol transport PMID: 24376702
    3. AQP7-specific glycerol transport was furthermore found to be specifically inhibited. PMID: 24334538
    4. REVIEW: the current knowledge on the role of the glycerol channels AQP7 and AQP9 in controlling glycerol metabolism in adipose tissue and liver PMID: 24463099
    5. AQP7 overexpression may be related to insulin sensitivity and glucose homeostasis in women with the polycystic ovary syndrome. PMID: 23235401
    6. AQP7 is expressed in human and mouse oocytes and upregulated by cryoprotectants. PMID: 23290745
    7. AQP7 is regulated in response to physical training in a gender-dependent manner in adipose tissue. PMID: 23001483
    8. The discovery of an association between urine glycerol loss and a platelet secretion defect is a novel one, and our findings imply the involvement of AQPs in platelet secretion. PMID: 22899094
    9. There is a coordinated regulation of adipose AQP7 and hepatic AQP9 gene expression that is distorted in metabolic syndrome X. PMID: 22425521
    10. In all of the 33 investigated semen samples, we observed AQP7 binding to the sperm sur-face with different intensity and modality. PMID: 22206455
    11. Diazoxide may have an impact on myocardial water balance and glycerol energy supply by decreasing relative aquaporin-7 expression during coronary artery bypass grafting. PMID: 21609198
    12. these data suggest a subtle regulation between adipose depots of the sole adipose aquaporin, AQP7, which is unbalanced in obesity and T2D. PMID: 20463097
    13. determination of genomic structure, promotor analysis and functional mutation PMID: 11952783
    14. In summary, our data show that the AQP7 gene is differentially expressed in adipose tissue of lean and obese individuals. PMID: 16325777
    15. AQP7 downregulation is pathogenic for obesity and/or type 2 diabetes. PMID: 17351148
    16. Dysfunction of AQP7 in the periadventitial fat may trigger the inflammation involved in aatherosclerosis. PMID: 17562358
    17. Expression of AQP7 is down-regulated in women with severe obesity. The expression of this glycerol channel is not affected by type 2 diabetes. PMID: 17566090
    18. increased gene expression in visceral adipose tissue and liver in morbid obesity PMID: 18401671
    19. we found a greater expression found in visceral fat, and between subcutaneous adipose AQP7 and hepatic aquaporin 9 gene expression within the context of human morbid obesity PMID: 19615702

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm, cell cortex. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lipid droplet.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Detected in the sperm head (at protein level). Detected in white adipose tissue.
  • 数据库链接：

    HGNC: 640

    OMIM: 602974

    KEGG: hsa:364

    STRING: 9606.ENSP00000297988

    UniGene: Hs.455323