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  4. Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1)

Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1)

  • 中文名称：
    Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1)
  • 货号：
    CSB-CF314084EEZ
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    BHRF1
  • Uniprot No.：
  • 别名：
    BHRF1; Apoptosis regulator BHRF1; Early antigen protein R; EA-R; Nuclear antigen
  • 种属：
    Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-191
  • 氨基酸序列
    MAYSTREILLALCIRDSRVHGNGTLHPVLELAARETPLRLSPEDTVVLRYHVLLEEIIER NSETFTETWNRFITHTEHVDLDFNSVFLEIFHRGDPSLGRALAWMAWCMHACRTLCCNQS TPYYVVDLSVRGMLEASEGLDGWIHQQGGWSTLIEDNIPGSRRFSWTLFLAGLTLSLLVI CSYLFISRGRH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell.
  • 基因功能参考文献：
    1. The interaction between EBV-miR-BHRF1-2 and PRDM1 may be one of the mechanisms by which EBV-miRBHRF1-2 promotes Epstein-Barr virus lymphomagenesis. PMID: 26530011
    2. 79V88V is the dominant variant in nasopharyngeal carcinoma and EBV-associated gastric carcinoma biopsies. PMID: 21114920
    3. The s report that Drosha cleavage of latency III BHRF1 RNA and cis-acting splicing effects inhibit splicing and inhibit BHRF1 RNA and protein expression. PMID: 21697496
    4. in lymphoid cells, BHRF1 binds a selective sub-set of pro-apoptotic proteins (Bid, Puma, Bak) expressed by host cells. PMID: 21203485
    5. viral miRNAs of the BHRF1 locus inhibit apoptosis and favor cell cycle progression and proliferation during the early phase of infected human primary B cells. PMID: 20808852
    6. Results indicate that EBV is essential for the survival of Burkitt lymphoma cells and that BHRF1 functions as a survival factor, and imply a critical contribution of BHRF1 to the pathogenesis of Wp-restricted BLs. PMID: 20042495
    7. killing of latently infected cells through the recognition of a protein produced during the lytic cycle is due to transfer of BHRF1 from lytically infected to latently infected cells, leading to their optimal recognition by BHRF1-specific CD4+ T cells PMID: 16339529
    8. human VRK2 interacts specifically with EBV BHRF1 and that the interaction is involved in protecting cells from apoptosis PMID: 16963744
    9. BHRF1 is constitutively expressed as a latent protein in growth-transformed cells in vitro and may contribute to virus-associated lymphomagenesis in vivo. PMID: 19283066
    10. BHRF1 may act either by binding preferentially the most lethal form of Bim or by acting catalytically on Bim to block apoptosis. PMID: 19293378

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  • 亚细胞定位：
    Host membrane; Single-pass membrane protein. Host mitochondrion.
  • 蛋白家族：
    Bcl-2 family
  • 数据库链接：

    KEGG: vg:3783706