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Recombinant Emerin homolog 1 (emr-1)

  • 中文名称：
    秀丽隐杆线虫emr-1重组蛋白
  • 货号：
    CSB-CF519041CXY
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    emr-1
  • Uniprot No.：
  • 别名：
    emr-1; M01D7.6; Emerin homolog 1; Ce-emerin
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-166
  • 氨基酸序列
    MDVSQLTDAELRDSLKSHGVSVGPIVATTRKLYEKKLIKLSDGSINNQSNLNDSQFNEDS LIISSSPKKSPPQRVFQNVSAATAAATTSPESDSDDCEESMRYLTEEEMAADRASARQAQ SNKGGFLGSTITFTILFVFIAVFAYFLIENAEQLKLVAETNPEDTI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with lem-2. May play a role in radiation-induced DNA damage repair response.
  • 基因功能参考文献：
    1. We demonstrate a specific role of EMR-1 in neuromuscular junction activity that may contribute to Emery-Dreifuss muscular dystrophy in humans PMID: 24490688
    2. these results clearly show that Ce-emerin and LEM-2 have additional roles in specific tissues, including striated muscle and smooth muscle. PMID: 22171324
    3. LEM domain proteins are essential for cell division and that Ce-emerin and Ce-MAN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery-Dreifuss muscular dystrophy PMID: 12684533
  • 亚细胞定位：
    Nucleus envelope. Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side.
  • 组织特异性：
    Ubiquitous. Expressed in all cells, except in cells undergoing spermatogenesis.
  • 数据库链接：

    KEGG: cel:CELE_M01D7.6

    STRING: 6239.M01D7.6.1

    UniGene: Cel.18441