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  4. Recombinant Drosophila melanogaster PDF receptor (Pdfr)

Recombinant Drosophila melanogaster PDF receptor (Pdfr)

  • 中文名称：
    黑腹果蝇Pdfr重组蛋白
  • 货号：
    CSB-CF894778DLU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Pdfr
  • Uniprot No.：
  • 别名：
    Pdfr; gop; Han; CG13758; PDF receptor; Pigment-dispersing factor receptor; Protein groom-of-PDF
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-669
  • 氨基酸序列
    MTLLSNILDCGGCISAQRFTRLLRQSGSSGPSPSAPTAGTFESKSMLEPTSSHSLATGRV PLLHDFDASTTESPGTYVLDGVARVAQLALEPTVMDALPDSDTEQVLGNLNSSAPWNLTL ASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTR KFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRT RTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRR GNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFP LKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFC FLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPLKTATNFAVWS YGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKRASMYSGAYNTA PDTDAVQPAGDPSATGKRISPPNKRLNGRKPSSASIVMIHEPQQRQRLMPRLQNKAREKG KDRVEKTDAEAEPDPTISHIHSKEAGSARSRTRGSKWIMGICFRGQKVLRVPSASSVPPE SVVFELSEQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for PDF, a neuropeptide controlling circadian behavioral rhythms. Probably regulates circadian behavioral rhythms through coordination of activities of clock neurons. PDF-binding results in the elevation of cAMP synthesis. Plays a role in sleep regulation and regulates the state transition from sleep to wake.
  • 基因功能参考文献：
    1. Body temperature rhythm (BTR) is fundamental for the maintenance of functions essential for homeostasis, such as generating metabolic energy and sleep. One major unsolved question is how body temperature decreases dramatically during the night. Previously, we demonstrated that a BTR-like mechanism, referred to as temperature preference rhythm (TPR), exists in Drosophila Here, we demonstrate that the diuretic hormone 31 (D PMID: 27852781
    2. Drosophila master pacemaker neurons perceive both PDF and glutamate via PDFR and mGluRA G-protein coupled receptors that increase or decrease intracellular cAMP, respectively in response to light stimulus. PMID: 25268747
    3. our study identified the Pigment Dispersing Factor Receptor (PdfR) as a regulator of flight circuit development and as a modulator of acute flight PMID: 24098151
    4. we show that PDF-R in pacemakers activates a different adenylate cyclase isoform PMID: 23929551
    5. PDFR activation in LN(v)s shifts the balance of circadian activity from evening to morning, similar to behavioral responses to summer-like environmental conditions PMID: 22938867
    6. PdfR is expressed by the muscles of the excretory system, and induces cAMP increases that underlie the myotropic effects of PDF. PMID: 22778427
    7. PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila PMID: 21559487
    8. Data suggest that small lateral PDF receptor-containing neurons directly target a subset of crucial pacemaker neurons, and that there is autocrine feedback signaling by PDF back to PDF-expressing cells. PMID: 20394051
    9. The data of this study establish the first synapse within the Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems. PMID: 16242402
    10. groom-of-PDF is a G protein-coupled receptor required for neuropeptide Pigment-Dispersing Factor neuron action in circadian behavior. PMID: 16242403
    11. Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons. PMID: 16242407
    12. Using circuit-directed rescue of PDF receptor mutants, data show that PDF targeting of just approximately 30 non-PDF evening circadian neurons is sufficient to drive morning behavior. PMID: 19621061

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 组织特异性：
    Mainly present in clock neurons of the brain. Localizes in all 4 s-LNv neurons, 1 LNd neuron, 7 DN1 neurons, and 1 DN3 neuron. In addition to the clock neurons, it is also present in approximately 13 pairs of neurons along the ventral nerve cord in third
  • 数据库链接：

    KEGG: dme:Dmel_CG13758

    STRING: 7227.FBpp0300789

    UniGene: Dm.17751