Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Dictyostelium discoideum P2X receptor A (p2xA)

Recombinant Dictyostelium discoideum P2X receptor A (p2xA)

  • 中文名称：
    盘基网柄菌p2xA重组蛋白
  • 货号：
    CSB-CF773000DKK
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    p2xA
  • Uniprot No.：
  • 别名：
    p2xA; DDB_G0272004; P2X receptor A; DdP2X; P2XA
  • 种属：
    Dictyostelium discoideum (Slime mold)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-378
  • 氨基酸序列
    MGFSFDWDDIFQYSTVKIVRIRDRRLGILHLSFLVGIVAYIVVYSAIIKKGYLFTEVPIG SVRTSLKGPNTFASNLTYCSNQQHNGSTYPFTPLECNYWDEQLALFPVGQDSTFTCTTRV RLSKQEANCNFTDPTCKFVDEPGSAKNIYIADIESFTILIDHTMYASSSGSQFNAVDLHG YILNQDGDEVQIDANGTSIGVSGKPDIMTIGQLLSFGGVSLDQASPVDSNVSIRYDGVVL FVFITYSNTYTYSTSDFKYVYSVQQIANTIYDVPETIILESIHSRLLYKRHGIRVIFIQT GTIGSFHFQTLLLTLVSGLGLLAVATTVVDQLAIRLLPQRKSYSSLKFQVTESMSNPMKK RITTDEGEDVLYTRIEGL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Inward currents evoked by intracellular ATP and ATP analogs. Exclusively selective for ATP over other nucleotides. Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. It has been reported that p2xA is not essential for osmoregulation, however this information is in contradiction with another source which indicates that p2xA is required for osmoregulation. Found to be permeable to chloride ions. Inhibited by copper and sodium ions.
  • 基因功能参考文献：
    1. P2X receptors localized on intracellular membranes in D. discoideum, are required for osmoregulation. PMID: 17625565
  • 亚细胞定位：
    Contractile vacuole membrane. Note=Ligand binding domain within the lumen of the vacuole.
  • 蛋白家族：
    P2X receptor family
  • 数据库链接：

    KEGG: ddi:DDB_G0272004

    STRING: 44689.DDB0238349