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  4. Recombinant Bovine Type II iodothyronine deiodinase (DIO2)

Recombinant Bovine Type II iodothyronine deiodinase (DIO2)

  • 中文名称：
    牛DIO2重组蛋白
  • 货号：
    CSB-CF686311BO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    DIO2
  • Uniprot No.：
  • 别名：
    DIO2; Type II iodothyronine deiodinase; 5DII; DIOII; Type 2 DI; Type-II 5'-deiodinase
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-269
  • 氨基酸序列
    MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGQWRRMLTSEGM RCIWKSFLLDAYKQVKLGEDAPNSSVVHVSSPEGGDTSGNGAQEKTVDGTECHLLDFASP ERPLVVNFGSATUPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLFF EVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAY LGGKGPFFYNLQEVRRWLEKNFSKRUKLD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
  • 基因功能参考文献：
    1. Increased expression of mammary TRbeta1 and DIO2, and decreased RXRalpha, provide a mechanism to increase thyroid hormone activity within the mammary gland during lactation. PMID: 18641053
  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    Iodothyronine deiodinase family
  • 组织特异性：
    Highly expressed in thyroid, mammary and pituitary glands, then in hypothalamus. Low levels detected in diaphragm, heart, kidney and lung.
  • 数据库链接：

    KEGG: bta:494548

    STRING: 9913.ENSBTAP00000002107

    UniGene: Bt.63066