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  4. Recombinant Adenosine monophosphate-protein transferase FICD homolog (ZK593.8)

Recombinant Adenosine monophosphate-protein transferase FICD homolog (ZK593.8)

  • 中文名称：
    秀丽隐杆线虫fic-1重组蛋白
  • 货号：
    CSB-CF638743CXY
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    fic-1
  • Uniprot No.：
  • 别名：
    fic-1; ZK593.8; Protein adenylyltransferase fic-1; De-AMPylase fic-1
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-508
  • 氨基酸序列
    MSVRRRTHSDDFSYLLEKTRRPSKLNVVQEDPKSAPPQGYSLTTVIIISVLVSLICQHFV PYAVSTLHTVIKNSPKQKSSPPPSNRLNIGFISGNSPEKYAPAVQKPTFLVDPIYDEKWK GIQTAVPVMSTQTDEKRENDPAKVKEAILAAKAAGRSRKDGNLERAMTIMEHAMALAPTN PQILIEMGQIREMHNELVEADQCYVKALAYDPGNSEALVLRARTTPLVSAIDRKMLRSVH DLRDEFNHLQHSTALRRMMRETYFLYVYHTVAIEGNTLSLGQTRAILESGMVIPGKSIRE HNEVIGMDAALRFLNCSLLSKEHDEISIDDILEMHRRVLGNADPVEAGRIRTTQVYVGRF TPVSPEYVMEQLKDIVDWLNDESTLTIDPIERAAIAHYKLVLVHPFTDGNGRTARLLLNL IMMRSGFPPVILPVETRAEYYASLHVANLGDLRPFVRYVAKHSEASIQRYIGAMKTSSDN ILNSGDSKLTPEESEVSEKIEAECRAGN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-274 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. In vivo target proteins include the heat-shock 70 family proteins hsp-1 and hsp-3 and the translation elongation factors eef-1A, eef-1G and eef-2. Can AMPylate core histone H3 in vitro. Can also act as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from target proteins. Decreases susceptibility to P.aeruginosa-mediated killing and might therefore play a role in the innate immune response.
  • 基因功能参考文献：
    1. We identify a link between FIC-1-mediated AMPylation and susceptibility to the pathogen Pseudomonas aeruginosa, establishing a connection between AMPylation and innate immunity in C. elegans PMID: 27138431
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
  • 蛋白家族：
    Fic family
  • 组织特异性：
    Ubiquitously expressed, with high expression in the germline.
  • 数据库链接：

    KEGG: cel:CELE_ZK593.8

    STRING: 6239.ZK593.8

    UniGene: Cel.17773