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  4. Recombinant Xenopus laevis Nodal homolog 3-A (nodal3-a)

Recombinant Xenopus laevis Nodal homolog 3-A (nodal3-a)

  • 中文名称：
    有爪蟾蜍nodal3-a重组蛋白
  • 货号：
    CSB-YP849596XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    有爪蟾蜍nodal3-a重组蛋白
  • 货号：
    CSB-EP849596XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    有爪蟾蜍nodal3-a重组蛋白
  • 货号：
    CSB-EP849596XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    有爪蟾蜍nodal3-a重组蛋白
  • 货号：
    CSB-BP849596XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    有爪蟾蜍nodal3-a重组蛋白
  • 货号：
    CSB-MP849596XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    nodal3-a
  • Uniprot No.：
  • 别名：
    nodal3-a; nr3; Nodal homolog 3-A; Nodal-related protein 3-A; Xnr3; Xnr3-A
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    275-401
  • 氨基酸序列
    NKKEKT QIHVSTVPPK PIEEIKPECK KVDMFVDFQK IGWGSWIIYP KAYNAYRCES TCAVPQNETE NATNHSYIKS LLPLSDMERK ECPSCVPMKM MSMSMLYYEN EDFILRHHEE MIVEECGFKD M
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation. The unprocessed protein antagonizes bmp-signaling.
  • 基因功能参考文献：
    1. The nodal3 genes of Xenopus laevis are present in gene clusters on chromosome XLA3L. This gene cluster has been completely lost from the syntenic S chromosome regions. Nodal3 genes in X. laevis and X. tropicalis were independently expanded and/or evolved in concert within each cluster by gene conversion. PMID: 27720224
    2. Xnr3 affects anterior ectoderm migration around the neural-epidermal boundary to induce a specific neural pattern abnormality. PMID: 24307296
    3. The pro-region of Nodal-related 3 is both necessary and sufficient for its BMP inhibition. PMID: 16762322
    4. The mature region of Nodal-related 3 entirely differs from other Nodal-related proteins in its mechanism of action. PMID: 17089091
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 组织特异性：
    Expressed in the epithelial layer of the Spemann organizer during gastrulation.
  • 数据库链接：

    KEGG: xla:378537

    UniGene: Xl.989