Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Tityus obscurus Toxin To49b

Recombinant Tityus obscurus Toxin To49b

  • 中文名称：
    Recombinant Tityus obscurus Toxin To49b,Yeast
  • 货号：
    CSB-YP350207TET
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Tityus obscurus Toxin To49b,Yeast
  • 货号：
    CSB-EP350207TET
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Tityus obscurus Toxin To49b,Yeast
  • 货号：
    CSB-EP350207TET-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Tityus obscurus Toxin To49b,Yeast
  • 货号：
    CSB-BP350207TET
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Tityus obscurus Toxin To49b,Yeast
  • 货号：
    CSB-MP350207TET
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    ; Beta-mammal/insect toxin To1; NaTx12.1; Toxin Tc49b
  • 种属：
    Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-84
  • 氨基酸序列
    KKEGYLVGND GCKYGCITRP HQYCVHECEL KKGTDGYCAY WLACYCYNMP DWVKTWSSAT NKCK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Beta toxin that show multiple effects. It enhances the open probability at more negative potentials of human Nav1.3/SCN3A and Nav1.6/SCN8A, of the insect channel BgNaV1 and of arachnid VdNaV1 channel. It promotes an important shift in slow inactivation processes as a function of the prepulse voltage in human Nav1.3/SCN3A and Nav1.6/SCN8A and a small shift in Nav1.1/SCN1A, Nav1.2/SCN2A and Nav1.4/SCN4A. Finally, it reduces the peak of sodium currents in Nav1.3/SCN3A (80% inhibition at 70 nM of toxin), Nav1.6/SCN8A (55.3%), Nav1.1/SCN1A (53.3%), Nav1.5/SCN5A (46.7%), Nav1.2/SCN2A (42.7%) and Nav1.4/SCN4A (20%) voltage-gated sodium channels. It has also been shown to affect the sodium current permeability of rat cerebellum granular cells in a partially reversible manner. In vivo, an intraperitoneal injection (20 ug) into mice produces excitability, respiratory problems, convulsions and death, within the first 30 minutes after injection.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
  • 组织特异性：
    Expressed by the venom gland.