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  4. Recombinant Sheep Pro-neuropeptide Y (NPY)

Recombinant Sheep Pro-neuropeptide Y (NPY)

  • 中文名称：
    绵羊NPY重组蛋白
  • 货号：
    CSB-YP016034SH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    绵羊NPY重组蛋白
  • 货号：
    CSB-EP016034SH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    绵羊NPY重组蛋白
  • 货号：
    CSB-EP016034SH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    绵羊NPY重组蛋白
  • 货号：
    CSB-BP016034SH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    绵羊NPY重组蛋白
  • 货号：
    CSB-MP016034SH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    NPY; Pro-neuropeptide Y [Cleaved into: Neuropeptide Y; Neuropeptide tyrosine; NPY); C-flanking peptide of NPY; CPON)]
  • 种属：
    Ovis aries (Sheep)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    29-64
  • 氨基酸序列
    YP SKPDNPGDDA PAEDLARYYS ALRHYINLIT RQRY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
  • 基因功能参考文献：
    1. NPY expression increases in the medial basal hypothalamus and arcuate and periventricular nuclei following fasting or intracerebroventricular (ICV) ghrelin infusion. PMID: 23085194
    2. Changes in the neuronal activity of hypothlamic arcuate NPY neurons between the prepubertal and peripubertal periods indicate that these neurons could be involved in mechanisms leading to puberty. PMID: 20637857
    3. The simultaneous increase of expression of hypothalamic NPY suggests NPY involvement in the regulation of psychoemotional stress through the somatotrophic axis in the female lambs. PMID: 20675289
    4. Data show that reciprocal connections exist between kisspeptin cells and NPY and POMC cells. PMID: 20207832
    5. results suggest that Neuropeptide Y (NPY) acts on the luteal vascular system and the large luteal cells to rapidly stimulate blood flow and the secretion of oxytocin implying a role for NPY in luteolysis PMID: 19782503
    6. NPY-ir neurons present in the infundibular nucleus can play a role in the preovulatory GnRH discharge from the median eminence PMID: 16584086
    7. Neuropeptide Y, agouti-related peptide, proopiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART), and insulin receptor mRNAs were all localized in the hypothalamic arcuate nucleus (ARC) of all fetuses. PMID: 18417651

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  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
  • 蛋白家族：
    NPY family
  • 组织特异性：
    One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
  • 数据库链接：

    KEGG: oas:443508

    UniGene: Oar.646