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  4. Recombinant Sheep C-type natriuretic peptide (NPPC)

Recombinant Sheep C-type natriuretic peptide (NPPC)

  • 中文名称：
    绵羊NPPC重组蛋白
  • 货号：
    CSB-YP016022SH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    绵羊NPPC重组蛋白
  • 货号：
    CSB-EP016022SH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    绵羊NPPC重组蛋白
  • 货号：
    CSB-EP016022SH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    绵羊NPPC重组蛋白
  • 货号：
    CSB-BP016022SH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    绵羊NPPC重组蛋白
  • 货号：
    CSB-MP016022SH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NPPC
  • Uniprot No.：
  • 别名：
    NPPC; CNPC-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53]
  • 种属：
    Ovis aries (Sheep)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    74-126
  • 氨基酸序列
    DLRVDTK SRAAWTRLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS MSGLGC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3.
  • 基因功能参考文献：
    1. CNP peptides in CSF decreased from day 4 to day 87 in pregnant sheep, possibly reflecting an adaptive response of the cerebral vasculature to increased hemodynamic load PMID: 25913855
    2. Concentrations of CNP forms in placental tissues greatly exceeded those in intercaruncular uterine tissue throughout pregnancy PMID: 21705079
    3. Circulating levels of paracrine CNP and amino-terminal fragment CNP are raised in experimental heart failure but to a much lesser degree than atrial peptide (ANP) and brain peptide (BNP). PMID: 16095755
    4. CNP is regulated independently in the fetus and mother PMID: 17510241
    5. strong relation to placental and fetal maturation; circulating concentration peaked at about d 120 PMID: 19608649

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Natriuretic peptide family
  • 数据库链接：

    KEGG: oas:493773

    UniGene: Oar.3302