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  4. Recombinant Saccharomyces cerevisiae Mitochondrial distribution and morphology protein 10 (MDM10)

Recombinant Saccharomyces cerevisiae Mitochondrial distribution and morphology protein 10 (MDM10)

  • 中文名称：
    酿酒酵母MDM10重组蛋白
  • 货号：
    CSB-YP325574SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母MDM10重组蛋白
  • 货号：
    CSB-EP325574SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母MDM10重组蛋白
  • 货号：
    CSB-EP325574SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母MDM10重组蛋白
  • 货号：
    CSB-BP325574SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母MDM10重组蛋白
  • 货号：
    CSB-MP325574SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MDM10
  • Uniprot No.：
  • 别名：
    MDM10; YAL010C; FUN37Mitochondrial distribution and morphology protein 10; Mitochondrial inheritance component MDM10
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-493
  • 氨基酸序列
    MLPYMDQVLR AFYQSTHWST QNSYEDITAT SRTLLDFRIP SAIHLQISNK STPNTFNSLD FSTRSRINGS LSYLYSDAQQ LEKFMRNSTD IPLQDATETY RQLQPNLNFS VSSANTLSSD NTTVDNDKKL LHDSKFVKKS LYYGRMYYPS SDLEAMIIKR LSPQTQFMLK GVSSFKESLN VLTCYFQRDS HRNLQEWIFS TSDLLCGYRV LHNFLTTPSK FNTSLYNNSS LSLGAEFWLG LVSLSPGCST TLRYYTHSTN TGRPLTLTLS WNPLFGHISS TYSAKTGTNS TFCAKYDFNL YSIESNLSFG CEFWQKKHHL LETNKNNNDK LEPISDELVD INPNSRATKL LHENVPDLNS AVNDIPSTLD IPVHKQKLLN DLTYAFSSSL RKIDEERSTI EKFDNKINSS IFTSVWKLST SLRDKTLKLL WEGKWRGFLI SAGTELVFTR GFQESLSDDE KNDNAISISA TDTENGNIPV FPAKFGIQFQ YST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
  • 基因功能参考文献：
    1. Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 complex PMID: 21036907
    2. Mdm10 regulates the timing of release of unassembled Tom40 from the TOB complex, to facilitate its coordinated assembly into the TOM40 complex PMID: 20111053
    3. Tom7-mediated segregation of Mdm10 functions by a differentiation of beta-barrel assembly PMID: 16760475
  • 亚细胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
  • 蛋白家族：
    MDM10 family
  • 数据库链接：

    KEGG: sce:YAL010C

    STRING: 4932.YAL010C