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  4. Recombinant Saccharomyces cerevisiae Histone H1 (HHO1)

Recombinant Saccharomyces cerevisiae Histone H1 (HHO1)

  • 中文名称：
    酿酒酵母HHO1重组蛋白
  • 货号：
    CSB-YP346469SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母HHO1重组蛋白
  • 货号：
    CSB-EP346469SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母HHO1重组蛋白
  • 货号：
    CSB-EP346469SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母HHO1重组蛋白
  • 货号：
    CSB-BP346469SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母HHO1重组蛋白
  • 货号：
    CSB-MP346469SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HHO1
  • Uniprot No.：
  • 别名：
    HHO1; YPL127C; LPI17C; Histone H1
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-258
  • 氨基酸序列
    MAPKKSTTKT TSKGKKPATS KGKEKSTSKA AIKKTTAKKE EASSKSYREL IIEGLTALKE RKGSSRPALK KFIKENYPIV GSASNFDLYF NNAIKKGVEA GDFEQPKGPA GAVKLAKKKS PEVKKEKEVS PKPKQAATSV SATASKAKAA STKLAPKKVV KKKSPTVTAK KASSPSSLTY KEMILKSMPQ LNDGKGSSRI VLKKYVKDTF SSKLKTSSNF DYLFNSAIKK CVENGELVQP KGPSGIIKLN KKKVKLST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Could act as an H1-type linker histone. Has been shown to bind DNA.
  • 基因功能参考文献：
    1. data suggest that complete absence of Hho1 from chromatin does not affect reciprocal recombination between homologous chromosomes during meiosis PMID: 26122007
    2. deletion of HHO1 gene in S. cerevisiae leads to alterations in the higher-order levels of chromatin organization. PMID: 22200500
    3. Hho1 may play a dual role during sporulation: Hho1 and Ume6 depletion facilitates the onset of meiosis via activation of Ume6-repressed early meiotic genes, whereas Hho1 enrichment in mature spores contributes to spore genome compaction. PMID: 22586276
    4. findings demonstrated that the two globular domains independently associated with two different four-way junction molecules in a manner that required amino acid residues implicated in structure-specific binding in the nucleosome PMID: 16342967
    5. Hho1p reinforces the action of several types of barrier elements, and also inhibits silencing on its own. PMID: 16582449
    6. results suggest that histone H1 represses recombination at the rDNA by a mechanism that is independent of the recombination pathways regulated by Sir2 PMID: 18179596
    7. Hho1p is involved in rDNA compaction, and like core histones, is required for efficient rDNA transcription by pol I PMID: 18687885
    8. Hho1p has a limited role in transcriptional regulation; this dynamically exchanging linker histone may be evicted from chromatin by transcriptional activity. PMID: 18799740
    9. mode of Hho1p action is similar to that of canonical linker histones PMID: 19017647

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Histone H1/H5 family
  • 数据库链接：

    KEGG: sce:YPL127C

    STRING: 4932.YPL127C