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  4. Recombinant Rat Zinc finger CCCH-type antiviral protein 1 (Zc3hav1)

Recombinant Rat Zinc finger CCCH-type antiviral protein 1 (Zc3hav1)

  • 货号：
    CSB-YP814321RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP814321RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP814321RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP814321RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP814321RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Zc3hav1
  • Uniprot No.：
  • 别名：
    Zc3hav1; ZapZinc finger CCCH-type antiviral protein 1; ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Inactive Poly [ADP-ribose] polymerase 13; PARP13; Zinc finger antiviral protein; ZAP; rZAP
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-776
  • 氨基酸序列
    ADPGVCCFI TKILCAHGGR MTLEELLGEI RLPEAQLYEL LETAGPDRFV LLETGGQAGI TRSVVATTRA RVCRRKYCQR PCDSLHLCKL NLLGRCHYAQ SQRNLCKYSH DVLSEQNFQI LKNHELSGLN QEELACLLVQ SDPFFLPEIC KSYKGEGRKQ TCGQPQPCER LHICEHFTRG NCSYLNCLRS HNLMDRKVLT IMREHGLSPD VVQNIQDICN NKHARRNPPG TRAAHPHRRG GAHRDRSKSR DRFLHNSLEF LSPVVSPLGS GPPSPDVTSC KDSLEDVSVD VTQKFKYLGT HDRAQLSPVS SKAAGVQGPS QMRASQEFSE DGNLDDIFSR NRSDSSSSRA SAAKVAQRNE AVAMKMGMEV KGKKEAPDID RVPFLNSYID GVTMEKASVS GIPGKKFTAN DLENLLLLND TWKNVAKPQD LQTTGRITDS GQDKAFLQNK YGGNPVWASA STHNAPNGSS QIMDETPNVS KSSTSGFAIK PAIAGGKEAV YSGVQSPRSQ VLAVPGEATT PVQSNRLPQS PLSSSSHRAA ASGSPGKNST HTSVSPAIES SRMTSDPDEY LLRYILNPLF RMDNHGPKEI CQDHLYKGCQ QSHCDRSHFH LPYRWQMFVY TTWRDFQDME SIEQAYCDPH VELILIENHQ INFQKMTCDS YPIRRLSTPS YEEKPLSAVF ATKWIWYWKN EFNEYIQYGN ESPGHTSSDI NSAYLESFFQ SCPRGVLPFQ AGSQKYELSF QGMIQTNIAS KTQRHVVRRP VFVSSNDVEQ KRRGPE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation.
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Expressed in the kidney and liver.
  • 数据库链接：

    STRING: 10116.ENSRNOP00000018782

    UniGene: Rn.199480