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Recombinant Rat Uromodulin (Umod)

  • 中文名称：
    大鼠Umod重组蛋白
  • 货号：
    CSB-YP025616RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Umod重组蛋白
  • 货号：
    CSB-EP025616RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Umod重组蛋白
  • 货号：
    CSB-EP025616RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Umod重组蛋白
  • 货号：
    CSB-BP025616RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Umod重组蛋白
  • 货号：
    CSB-MP025616RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Umod
  • Uniprot No.：
  • 别名：
    UmodUromodulin; Tamm-Horsfall urinary glycoprotein; THP) [Cleaved into: Uromodulin; secreted form]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-615
  • 氨基酸序列
    NDSPE ARRCSECHDN ATCVLDGVVT TCSCQAGFTG DGLVCEDIDE CATPWTHNCS NSICMNTLGS YECSCQDGFR LTPGLGCIDV NECTEQGLSN CHSLATCVNT EGSYSCVCPK GYRGDGWYCE CSPGFCEPGL DCLPQGPSGK LVCQDPCNVY ETLTEYWRST DYGAGYSCDS DMHGWYRFTG QGGVRMAETC VPVLRCNTAA PMWLNGSHPS SREGIVSRTA CAHWSDHCCL WSTEIQVKAC PGGFYVYNLT EPPECNLAYC TDPSSVEGTC EECGVDEDCV SDNGRWRCQC KQDFNVTDVS LLEHRLECEA NEIKISLSKC QLQSLGFMKV FMYLNDRQCS GFSERGERDW MSIVTPARDG PCGTVLRRNE THATYSNTLY LASEIIIRDI NIRINFECSY PLDMKVSLKT SLQPMVSALN ISLGGTGKFT VQMALFQNPT YTQPYQGPSV MLSTEAFLYV GTMLDGGDLS RFVLLMTNCY ATPSSNSTDP VKYFIIQDRC PHTEDTTIQV TENGESSQAR FSIQMFRFAG NSDLVYLHCE VYLCDTMSEQ CKPTCSGTRY RSGNFIDQTR VLNLGPITRQ GVQAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.; In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
  • 基因功能参考文献：
    1. Two forms of uromodulin (polymerization competent and polymerization incompetent) were found in urine from both Wistar-Kyoto and SHRSP, where the polymerization-incompetent form was increased in a pregnancy-specific manner in stroke-prone spontaneously hypertensive rats. PMID: 28348009
    2. results demonstrate a selective decrease in medullary THP synthesis, suggesting a potential involvement of THP in the renal functional changes associated with hypothyroidism PMID: 15007654
    3. Tamm-Horsfall protein derived from hyperoxaluric rats exhibited 2-fold increase in the Ca*Ox binding when compared to controls PMID: 15992786
    4. Sepsis-induced renal Cox-2 expression on TLR4 is tubule specific. The TLR4-dependent Cox-2 expression is mostly restricted to cortical and medullary thick ascending loops of Henle that characteristically express and secrete Tamm-Horsfall protein. PMID: 17634395
    5. The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens. PMID: 18830570

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  • 亚细胞定位：
    Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane.; [Uromodulin, secreted form]: Secreted.
  • 组织特异性：
    Expression restricted to the thick ascending limb of the loop of Henle (TALH).
  • 数据库链接：

    KEGG: rno:25128

    STRING: 10116.ENSRNOP00000021027

    UniGene: Rn.31982