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  4. Recombinant Rat Tyrosine-protein kinase Mer (Mertk), partial

Recombinant Rat Tyrosine-protein kinase Mer (Mertk), partial

  • 货号：
    CSB-MP013706RA
  • 规格：
    ￥3960
  • 图片：
    • Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP013706RA could indicate that this peptide derived from Mammalian Cell-expressed Rattus norvegicus (Rat) Mertk.
    • Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP013706RA could indicate that this peptide derived from Mammalian Cell-expressed Rattus norvegicus (Rat) Mertk.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Mertk; MerTyrosine-protein kinase Mer; EC 2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 来源：
    Mammalian cell
  • 分子量：
    55.5
  • 表达区域：
    19-497aa
  • 氨基酸序列
    GGTAEKEEEIKPDQPFSGPLPGSLPADHRPFFAPHSSGDQLSPSQTGRSHPAHTATPQMTSAASNLLPPVAFKNTIGRIVLSEHKSVKFNCSINIPNVYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSITSVQRSDNGSYICKMKVNDREVVSDPIYVEVQGLPYFTKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNENPERSPSVLTVAGLTETAVFSCEAHNDKGLTVSKGVQINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADQLSNGSVMVFNTSASPHLYEVQQLQALANYSVTVSCRNEIGWSAVSPWILASTTEGAPAVAPLNITVFLNESSNNLEIRWTKPPIKRQDGELVGYRISHVWESAGTSKELSEEVSQNGSWAQVPVQMHNATCTVRIAVITKGGIGPFSEPVDVAIPEHSRVDYAPSSTPAPGNTESM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
  • 基因功能参考文献：
    1. Mertk protein expression in the Bone marrow mesenchymal stem cells was similar to that in the retinal pigment epithelial cells in the primary passage. PMID: 28210098
    2. study concludes that activated microglia release Gal-3 and a neuraminidase that desialylates microglial and PC12 surfaces, enabling Gal-3 binding to PC12 (neuron-like) cells and their phagocytosis via Mer tyrosine kinase (MerTK). PMID: 28500071
    3. This study demonstrated that in Mertk mutation mice regulated the Expression pattern of Ccr2 and Cx3cr1. PMID: 26458944
    4. A novel role of MERTK signaling in membrane trafficking in the Retinal Pigment Eepithelium that is likely to subserve mechanisms of phagosome formation. PMID: 26283020
    5. A deletion in the Mer tyrosine kinase (MerTK) receptor in Royal College of Surgeons rat that abolishes internalization of photoreceptor outer segments by retinal pigment epithelial cells. PMID: 20238011
    6. Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells. PMID: 11861639
    7. Key involvement of mer in outer segment phsgocytosis has been clearly proven. PMID: 15180281

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  • 相关疾病：
    Defects in Mertk are the cause of retinal dystrophy (rdy) in the royal college of surgeons (RCS) rats.
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily
  • 数据库链接：

    KEGG: rno:65037

    STRING: 10116.ENSRNOP00000023419

    UniGene: Rn.48789