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  4. Recombinant Rat Transcription factor HES-1 (Hes1)

Recombinant Rat Transcription factor HES-1 (Hes1)

  • 中文名称：
    大鼠Hes1重组蛋白
  • 货号：
    CSB-YP010307RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Hes1重组蛋白
  • 货号：
    CSB-EP010307RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Hes1重组蛋白
  • 货号：
    CSB-EP010307RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Hes1重组蛋白
  • 货号：
    CSB-BP010307RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Hes1重组蛋白
  • 货号：
    CSB-MP010307RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Hes1; Hes-1; Hl; Transcription factor HES-1; Hairy and enhancer of split 1; Hairy-like protein; RHL
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-281
  • 氨基酸序列
    MPADIMEKNS SSPVAATPAS VNTTPDKPKT ASEHRKSSKP IMEKRRRARI NESLSQLKTL ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRAQMTAAL STDPSVLGKY RAGFSECMNE VTRFLSTCEG VNTEVRTRLL GHLANCMTQI NAMTYPGQAH PALQAPPPPP PSGPGGPQHA PFAPPPPLVP IPGGAAPPPG SAPCKLGSQA GEAAKVFGGF QVVPAPDGQF AFLIPNGAFA HSGPVIPVYT SNSGTSVGPN AVSPSSGSSL TADSMWRPWR N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
  • 基因功能参考文献：
    1. MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1 PMID: 30107165
    2. This study showed that overexpression of microRNA381 promotes cell proliferation of neurocytes in spinal cord injury via Hes1 expression. PMID: 29750292
    3. Hes1 is upregulated and mediates cardioprotection provided by ischemic postconditioning and suggest that Hes1 is a potential new target for the treatment of ischemic cardiomyopathy. PMID: 25431316
    4. Hes-1 may play an important role in the pathogenesis of asthma. PMID: 24927445
    5. results indicate that HES1 acts as a master repressor, the silencing of which is required for proper glucocorticoid signaling. PMID: 24300895
    6. The rate of mortality, frequency of spontaneous recurrent seizures and incidence of epileptiform waves show a tendency to decrease after treatment with Hes1-bone marrow stromal cell transplantation in epileptic rats. PMID: 22521826
    7. After ischemia and reperfusion, Hes1 intracellular domain level in ischemic striatum in electroacupuncture pretreatment group were increased and reached the peak at 2 h and 24 h. PMID: 22989188
    8. The induction of the EL-box-containing promoter by BMAL1/CLOCK or BMAL1/NPAS2 was suppressed by HES1, whereas HES1 does not show any suppressive effect on the E-box element. PMID: 22960268
    9. JNK1 phosphorylation of Hes-1 stabilizes the Hes-1 protein and enhances the suppressing effect of Hes-1 on GluR1 expression. PMID: 22302822
    10. Hes1 was expressed on postnatal days 0 - 3 in rat greater epithelial ridge cells. PMID: 16335396
    11. Data indicate that exposure of hippocampal neural precursor cells to TNFalpha during differentiation but not proliferation has a detrimental effect on their neuronal lineage fate, which may be mediated through increased expression of Hes1. PMID: 19840854
    12. HES-1 is a regulator of intracellular signal transduction stimulated by cell adhesion molecules involved in neurite outgrowth. PMID: 12478609
    13. Regulated lipocalin-type prostaglandin D synthase gene expression through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells. PMID: 12488457
    14. Hes1 can drive GRPs to an astrocyte cell fate at the expense of oligodendrocyte differentiation. PMID: 12666205
    15. The ability of truncated versions of Hes1 to bind Ptf1-p48 correlates with their ability to down-regulate the activity of the PTF1 transcriptional complex. PMID: 16201968

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Present in all tissues examined but highest in epithelial cells and in mesoderm-derived tissues such as embryonal muscle cells.
  • 数据库链接：

    KEGG: rno:29577

    STRING: 10116.ENSRNOP00000002346

    UniGene: Rn.19727