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  4. Recombinant Rat Thyrotropin subunit beta (Tshb)

Recombinant Rat Thyrotropin subunit beta (Tshb)

  • 中文名称：
    大鼠Tshb重组蛋白
  • 货号：
    CSB-BP025130RA
  • 规格：
    ￥3168
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    TshbThyrotropin subunit beta; Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Baculovirus
  • 分子量：
    16.9 kDa
  • 表达区域：
    21-132aa
  • 氨基酸序列
    FCIPTEYMMYVDRRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFTYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHEAVKTNYCTKPQTFY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    CUSABIO used the Rat Thyrotropin subunit beta (Tshb) DNA sequence encoding amino acids 21-132 to generate a fusion protein with an N-terminal 10xHis-tag and a C-terminal Myc-tag. The resulting recombinant full-length of mature protein was produced in the Baculovirus. It was subjected to SDS-PAGE (15% gel) under reducing conditions and presented a molecular mass band of about 19 kDa on the gel. The purity of the Tshb protein is greater than 85%. In addition to specific antibody synthesis, this recombinant Tshb protein may be used in the studies of Tshb-involved cancers.

    Tshb, together with Tsha, makes up the thyrotropin (TSH). Tshb determines the specificity of TSH, which is responsible for the activation of the thyroid gland, playing a key role in controlling development and metabolism in mammals and other vertebrates. TSH is also involved in the specific developmental processes such as larval metamorphosis in amphibians, as well as larval and secondary metamorphoses in some teleost species. Additionally, TSH may regulate the functions in immune or reproductive systems through pleiotropic effects and multiple target tissues of thyroid hormones.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Indispensable for the control of thyroid structure and metabolism.
  • 基因功能参考文献：
    1. These data add new insight to an important role of T3 in rapidly regulating TSH beta gene expression at posttranscriptional level. PMID: 21078364
    2. TSH action stimulates the phosphorylation of hsp-90 in FRTL-5 thyroid cells PMID: 16910874
    3. Results clearly show that there are diurnal changes in TSH expression and accumulation in rat PT-TSH cells and suggest that these fluctuations are regulated by melatonin. PMID: 17927662
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glycoprotein hormones subunit beta family
  • 数据库链接：

    KEGG: rno:25653

    STRING: 10116.ENSRNOP00000022575

    UniGene: Rn.9966