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  4. Recombinant Rat Small conductance calcium-activated potassium channel protein 1 (Kcnn1), partial

Recombinant Rat Small conductance calcium-activated potassium channel protein 1 (Kcnn1), partial

  • 中文名称：
    大鼠Kcnn1重组蛋白
  • 货号：
    CSB-YP012083RA1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Kcnn1重组蛋白
  • 货号：
    CSB-EP012083RA1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Kcnn1重组蛋白
  • 货号：
    CSB-EP012083RA1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Kcnn1重组蛋白
  • 货号：
    CSB-BP012083RA1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Kcnn1重组蛋白
  • 货号：
    CSB-MP012083RA1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcnn1
  • Uniprot No.：
  • 别名：
    Kcnn1; Sk1; Small conductance calcium-activated potassium channel protein 1; SK1; SKCa 1; SKCa1; KCa2.1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
  • 基因功能参考文献：
    1. SK channel current is a substantial element in sustaining the substantia nigra pars compacta dopaminergic neuroal rhythmic pacemaking. PMID: 24841382
    2. This study demonistrated that SK1 and SK2 transcripts showed strong expression starting from E15 in the striatum and decreased throughout pre- and postnatal development. PMID: 24096910
    3. Small conductance Ca(2+)-activated K(+) (SK) channels expressed in the hypothalamic paraventricular nucleus play an important role in the regulation of sympathetic outflow and cardiovascular function. PMID: 22647293
    4. expressed in myometrium throughout pregnancy and contribute to outward current, regulate membrane potential and calcium signalling PMID: 19969350
    5. rSK1 subunit is synthesized in cells but does not form functional homomeric channels PMID: 14761961
    6. These results implicate SK1 subunits as key regulators of excitability and endocrine function in beta cells. PMID: 19101546
    7. downregulation of SK1 and SK3 channels and upregulation of SK2 channels provide direct evidence that these Ca2+-activated K+ channels play important roles in inferior colliculi neuronal hyperexcitability that leads to inherited seizure susceptibility PMID: 19254702

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel KCNN family, KCa2.1/KCNN1 subfamily
  • 组织特异性：
    Widely expressed including brain.
  • 数据库链接：

    KEGG: rno:54261

    STRING: 10116.ENSRNOP00000042517

    UniGene: Rn.44422