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  4. Recombinant Rat Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Ppp1cc)

Recombinant Rat Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Ppp1cc)

  • 中文名称：
    大鼠Ppp1cc重组蛋白
  • 货号：
    CSB-YP018505RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Ppp1cc重组蛋白
  • 货号：
    CSB-EP018505RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Ppp1cc重组蛋白
  • 货号：
    CSB-EP018505RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Ppp1cc重组蛋白
  • 货号：
    CSB-BP018505RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Ppp1cc重组蛋白
  • 货号：
    CSB-MP018505RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ppp1cc; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; PP-1G; EC 3.1.3.16; Protein phosphatase 1C catalytic subunit
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-323
  • 氨基酸序列
    ADIDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE KKKPNATRPV TPPRGMITKQ AKK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.; Required for normal male fertility.
  • 基因功能参考文献：
    1. that PPP1CC promoted astrocyte and microglia proliferation after inflammation PMID: 29033188
    2. Data suggest that Ncx1 (sodium-calcium exchanger 1) is substrate-specifying Pp1c regulator protein, regulating Ncx1 activity via Ser-68-phospholemman (Plm) dephosphorylation in cardiomyocytes; Plm/Ncx1/Pp1c complex is up-regulated in heart failure. PMID: 26668322
    3. Fe65 is the bridging protein to amyloid-beta protein precursor in the complex formed and thus we simultaneously describe another PP1 binding protein PMID: 23531501
    4. Agonist-induced dephosphorylation of mGluR7 is regulated by PP1. PMID: 23612982
    5. glutamate receptors type 1a, 5a, and 5b bind to protein phosphatase 1C PMID: 14519764
    6. there is a protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin PMID: 15016827
    7. protein phosphatase 1 catalytic subunits bind to O-GlcNAc transferase PMID: 15247246
    8. phosphorylated MYPT dissociates from PP1 so that PP1 is no longer physically associated with myosin light chain 2 in cardiac myocytes PMID: 15908465
    9. Taken together, these results suggest that vimentin is a novel member of binding partner of PP1c in astrocytes, and vimentin-Ser82 may act as a memory phosphorylation site. PMID: 16629905
    10. selective targeting of PP1gamma1 to F-actin by neurabins 1& 2 in intact cells requires both the canonical PP1-binding motif and an auxiliary PP1gamma1-selectivity determinant PMID: 18216290
    11. striatal dopamine depletion inhibits a specific synaptic phosphatase by increasing PP1gamma(1) interaction with spinophilin PMID: 18372251

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cleavage furrow. Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome, centromere, kinetochore. Nucleus speckle. Midbody. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center.
  • 蛋白家族：
    PPP phosphatase family, PP-1 subfamily
  • 组织特异性：
    Isoform 2 is expressed only in testis, in the late spermatocytes and early spematids (at protein level).
  • 数据库链接：

    KEGG: rno:24669

    STRING: 10116.ENSRNOP00000047912

    UniGene: Rn.1495