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  4. Recombinant Rat SH2B adapter protein 3 (Sh2b3)

Recombinant Rat SH2B adapter protein 3 (Sh2b3)

  • 中文名称：
    大鼠Sh2b3重组蛋白
  • 货号：
    CSB-YP021208RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Sh2b3重组蛋白
  • 货号：
    CSB-EP021208RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Sh2b3重组蛋白
  • 货号：
    CSB-EP021208RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Sh2b3重组蛋白
  • 货号：
    CSB-BP021208RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Sh2b3重组蛋白
  • 货号：
    CSB-MP021208RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Sh2b3; Lnk; SH2B adapter protein 3; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-368
  • 氨基酸序列
    MAGRTQGKHR PRVRTCPSLV PFDNPCWPPS HQPLPLQVGA PGHRVTSFLS GRAWPSYIPK GKHGLPGPRY VPDPWSLGVL GHVAPLRVTT TIFLPGASPG VMLDPACQKT DHFLSCYPWF HGPISRVRAA QLVQLQGPDA HGVFLVRQSE SRRGEYVLTF NLQGRAKHLR LVLTERGQCR VQHLHFPSVV DMLRHFQRSP IPLECGAACD VRLSGYVVVV SQAPGRKPKV VSRGGVTAST ARTKLPSWLR LLHGVIHVIS PGSSNTVLFP FSLPHWDSEL GHPHLSSAGC PPGHGAEALR GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYE MDSSSRSHLR AIDNQYTPLS QLCREANL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
  • 基因功能参考文献：
    1. These data demonstrate for the first time that SH2B3 is a crucial mediator of post-MI inflammation and fibrosis. PMID: 25628389
    2. SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure. PMID: 26101343
    3. The resulting mutation was a 6-bp, in-frame deletion within a highly conserved region of the Src homology 2 (SH2) domain of SH2B3. This mutation significantly attenuated Dahl SS hypertension and renal disease. PMID: 25776069
    4. SH2B3 inhibits neuronal differentiation of PC12 cells and primary cortical neurons PMID: 22028877
  • 蛋白家族：
    SH2B adapter family
  • 组织特异性：
    Preferentially expressed by lymphocytes in lymph node and spleen.
  • 数据库链接：

    KEGG: rno:58838

    STRING: 10116.ENSRNOP00000066850

    UniGene: Rn.11228