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  4. Recombinant Rat Ribonuclease UK114 (Hrsp12)

Recombinant Rat Ribonuclease UK114 (Hrsp12)

  • 中文名称：
    大鼠Rida重组蛋白
  • 货号：
    CSB-YP010744RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Rida重组蛋白
  • 货号：
    CSB-EP010744RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Rida重组蛋白
  • 货号：
    CSB-EP010744RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Rida重组蛋白
  • 货号：
    CSB-BP010744RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Rida重组蛋白
  • 货号：
    CSB-MP010744RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rida
  • Uniprot No.：
  • 别名：
    Rida; Psp1; 2-iminobutanoate/2-iminopropanoate deaminase; EC 3.5.99.10; Liver perchloric acid-soluble protein; L-PSP; Reactive intermediate imine deaminase A homolog; Translation inhibitor L-PSP ribonuclease; UK114 antigen homolog; rp14.5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-137
  • 氨基酸序列
    SSIIRKVISTSKAPAAIGAYSQAVLVDRTIYVSGQIGMDPSSGQLVPGGVAEEAKQALKN LGEILKAAGCDFTNVVKTTVLLADINDFGTVNEIYKTYFQGNLPARAAYQVAALPKGSRI EIEAIAVQGPFTTAGL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.; Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.
  • 基因功能参考文献：
    1. These studies define new roles for glucocorticoid receptor, Y-box binding protein 1, and RNase UK114 in the formation of a molecular complex that degrades MCP-1 mRNA. PMID: 22801372
    2. first report on the presence of perchloric acid soluble protein (PSP)in rat lung and on its involvement in the regulation of cellular growth and differentiation [Hrsp12]. PMID: 12798936
    3. expression of perchloric acid-soluble protein PSP in rat hepatoma was down regulated as compared with intact tissue. PMID: 12939504
    4. PSP is involved in the cellular response to ER stressors, and that the change in localization of PSP from the endoplasmic reticulum to the nucleus may be associated with endoplasmic reticulum stress responses. PMID: 16081652
    5. Expression of PSP protein and mRNA decreased and then gradually increased during liver regeneration PMID: 16428853
    6. Intestinal PSP expression was induced by approximately 3-fold by oral administration of dietary fat PMID: 16843601

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Peroxisome. Mitochondrion.
  • 蛋白家族：
    RutC family
  • 组织特异性：
    Liver and kidney.
  • 数据库链接：

    KEGG: rno:65151

    STRING: 10116.ENSRNOP00000007430

    UniGene: Rn.6987