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Recombinant Rat Proenkephalin-A (Penk)

  • 中文名称：
    大鼠Penk重组蛋白
  • 货号：
    CSB-YP017781RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Penk重组蛋白
  • 货号：
    CSB-EP017781RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Penk重组蛋白
  • 货号：
    CSB-EP017781RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Penk重组蛋白
  • 货号：
    CSB-BP017781RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Penk重组蛋白
  • 货号：
    CSB-MP017781RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Penk
  • Uniprot No.：
  • 别名：
    Penk; Penk-rs; Penk1; Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin; Opioid growth factor; OGF); PENK(114-133); PENK(143-185); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(239-260); Met-enkephalin-Arg-Phe]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    25-97
  • 氨基酸序列
    DCSQDC AKCSYRLVRP GDINFLACTL ECEGQLPSFK IWETCKDLLQ VSKPEFPWDN IDMYKDSSKQ DESHLLA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; Increases glutamate release in the striatum and decreases GABA concentration in the striatum.; Increases glutamate release in the striatum.
  • 基因功能参考文献：
    1. Preproenkephalin-minimalistic immunologically defined gene expression-nuclear localization signal (PPENK-MIDGE-NLS) vector postconditioning can mitigate myocardial ischemia reperfusion injury by promoting mitophagy. PMID: 29169417
    2. Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rat forebrain has been reported. PMID: 28423013
    3. The findings of thus study suggest that, in parkinsonian animals treated with l-DOPA, high levels of PPENK are a prerequisite for a locomotor sensitization to l-DOPA treatment PMID: 27072528
    4. results suggest that a DeltaFosB-mediated downregulation of enkephalin in the nucleus accumbens might underlie the susceptibility to chronic stress PMID: 24090157
    5. Enkephalin expression was increased in the paraventricular nucleus in high ethanol consuming rats with high activity compared to low activity. PMID: 22725682
    6. we have demonstrated that ENKergic neurons facilitate unconditioned fear and anxiety through ENK release PMID: 23368426
    7. enkephalin surges and mu opioid stimulation in the same anteromedial dorsal neostriatumregion contribute to signaling the opportunity to eat a sensory reward and to causally generating increased consumption of that reward. PMID: 23000149
    8. The results of this study showed that dense ENK-ir fibers and terminals and GABA-ir cell bodies, fibers, and terminals were observed in the nucleus tractus solitarius. PMID: 20686827
    9. Elevated expression levels of enkephalin are found in the hypothalamus of rats predicted to consume high levels of ethanol. PMID: 20692550
    10. Normal-weight rats predicted to overconsume a fat-rich diet exhibit disturbances in endogenous enkephalin expression and functioning that may contribute to their long-term, behavioral phenotype. PMID: 20603139
    11. proenkephalin is sorted to the regulated secretory pathway at the trans-Golgi network by a mechanism involving the interaction of a specific sorting signal on these molecules with the sorting receptor [review] PMID: 12438160
    12. there are gender differences in the response of chronic exposure to cannabinoids on proenkephalin gene expression in the hypothalamus PMID: 12503826
    13. Systemic immune challenge induces preproenkephalin gene transcription in distinct autonomic structures of the rat brain. PMID: 12811812
    14. 60% and 40% of olfactory tubercle neurons projecting to the ventrolateral portion of the ventral pallidum were immunoreactive for PPD and PPE, respectively, as were the accumbens nucleus neurons. PMID: 12895518
    15. These results suggest that endogenous opioids could play a major role in controlling sympathetic outflow to the bladder through a direct action on sympathetic preganglionic neurons. PMID: 15952166
    16. Alterations in enkephalin expression in the substantia nigra and CP in response to ethanol exposure could be involved in the mechanisms underlying brain sensitivity to the drug. PMID: 18227978

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  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen.
  • 蛋白家族：
    Opioid neuropeptide precursor family
  • 组织特异性：
    Expressed in brain, heart and testis.
  • 数据库链接：

    KEGG: rno:29237

    STRING: 10116.ENSRNOP00000011892

    UniGene: Rn.10015