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  4. Recombinant Rat P2X purinoceptor 3 (P2rx3), partial

Recombinant Rat P2X purinoceptor 3 (P2rx3), partial

  • 中文名称：
    大鼠P2rx3重组蛋白
  • 货号：
    CSB-YP017321RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠P2rx3重组蛋白
  • 货号：
    CSB-EP017321RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠P2rx3重组蛋白
  • 货号：
    CSB-EP017321RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠P2rx3重组蛋白
  • 货号：
    CSB-BP017321RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠P2rx3重组蛋白
  • 货号：
    CSB-MP017321RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    P2rx3; P2X purinoceptor 3; P2X3; ATP receptor; Purinergic receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for ATP that acts as a ligand-gated cation channel. Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception.
  • 基因功能参考文献：
    1. These results suggest that animal-specific increases in P2X3-R mRNA levels are likely associated with the genetic/epigenetic context of the P2X3-R locus that controls P2X3-R gene transcription by recruiting Runx1 and epigenetic co-regulators that mediate histone acetylation. PMID: 29219199
    2. The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel. PMID: 29636447
    3. P2X3Rs are physically and functionally interconnected at the presynaptic level to control synaptic activities in the right insular cortex, thus contributing to visceral pain of neonatal maternal deprivation rats. PMID: 29560791
    4. Study found that the locus coeruleus/norepinephrine-sympathoadrenomedullary system was involved in the mediation of empathy for pain in pain-naive cagemate observer rats through up-regulating P2X3 receptors in the DRG by elevating circulating norepinephrine. Meanwhile, in the periphery, the sympatho-postganglionic source of norepinephrine might enhance the action of P2X3 receptor through acting on alpha1 adrenoceptor. PMID: 28979194
    5. electroacupuncture (EA) has a parameter-specific effect on chronic inflammatory pain relief, which primarily depend on the stimulation frequency and not on the stimulation time at a certain stimulation time. The parameter-specific analgesic effect of EA is at least partially related to mediation of the protein level of TRPV1 and P2X3 expression in DRG of CFA rats. PMID: 29550358
    6. P2rx3 mRNA expression is upregulated substantially in chemoreceptive petrosal sensory neurons in rats with hypertension. These neurons generate both tonic drive and hyperreflexia in hypertensive (but not normotensive) rats, and both phenomena are normalized by the blockade of P2X3 receptors. PMID: 27595323
    7. Heart failure upregulated the protein expression of kinin B2 and P2X3 in dorsal root ganglion. PMID: 27802438
    8. The aim of this study was to investigate the effects of lncRNA uc.48+ small interfering RNA (siRNA) on diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root PMID: 26686228
    9. Results indicate that the upregulated expression of P2X3 receptors in trigeminal subnucleus caudalis and midbrain periaqueductal gray may contribute toward the development of orofacial pain induced by occlusal interference and P2X3 receptors in the periaqueductal gray may play a key role in the supraspinal antiociception effect PMID: 26836462
    10. The P2X3-immunoreactive nerve endings may be classified into two types, i.e., intraepithelial ramified nerve endings and nerve endings associated with chemosensory cells and neuroendocrine cells. PMID: 26475709
    11. Data suggest that up-regulation of P2x3r gene promoter DNA demethylation and enhanced interaction with p65 (nuclear factor kappa B subunit p65) in neurons of dorsal root ganglion contributes to P2x3r sensitization and peripheral diabetic neuropathy. PMID: 26130762
    12. discovered a dual link between purinoceptors P2Xand mu-opioid receptors PMID: 25592684
    13. a decrease in the expression of P2X3 receptors in the periaqueductal gray of diabetic rats is likely to impair the descending inhibitory system in modulating pain transmission and thereby contributes to the development of mechanical allodynia in diabetes PMID: 25367719
    14. The expression of P2X3 receptors is upregulated in the dorsal root ganglia and smooth muscle of the corpus cavernosum in rats with thoracic or sacral spinal cord transection. PMID: 24387161
    15. Results suggest that P2X3 and TRPV1 interact in a facilitatory manner, which could contribute to the peripheral sensitization known to underlie masseter hyperalgesia PMID: 23201260
    16. Enhanced adrenergic signaling sensitizes the P2X3Rs in primary sensory neurons, mediating mechanical hyperalgesia in chronic pancreatitis. PMID: 25634810
    17. Cast immobilization produced a time-dependent increase in p2x3 PMID: 24154957
    18. Neuronal P2X3 receptor activation increases susceptibility to inflammatory mediators in the development of hyperalgesia. PMID: 23186588
    19. expression of the P2X(3)receptors in the DRG may be induced by local application of nucleus pulposus PMID: 22790888
    20. Findings suggest that P2X3R expression associated with enhanced IL-1beta expression and ATP release in masseter muscle (MM) has a possible important role in MM mechanical hyperalgesia after excessive muscular contraction. PMID: 23520364
    21. Results suggest that the P2X(3) receptor is functionally up-regulated in dorsal root ganglia in rats with bone cancer pain. PMID: 22528605
    22. A functional interaction of the P2X3 ATP receptor with PAR-2 in rat dorsal root ganglia neurons contributes to inflammatory pain. PMID: 22616675
    23. These data suggest that P2X3 and/or P2X2/3 receptors have a broad contribution to somatosensory/nociceptive transmission in rats with a chronic inflammatory injury PMID: 22422599
    24. These results indicate that P2X(3) receptor-activated signals are transmitted via retrogradely transported endosomes in primary sensory neurons and provide a novel signaling mechanism for ligand-gated channels. PMID: 22157653
    25. Subcutaneous injection of botulinum toxin type A significantly reverses neuropathic pain behavior and over-expression of P2X3 receptor in nociceptive neurons. PMID: 21810163
    26. Data suggest that puerarin may alleviate neuropathic pain mediated by P2X(3) receptors in dorsal root ganglion neurons. PMID: 22044944
    27. The results suggest that the membrane microenvironment of trigeminal sensory neurons is an important factor in determining sensitization of P2X3 receptors and could contribute to a migraine phenotype by enhancing ATP-mediated responses. PMID: 21958474
    28. These results indicate that estrogen might modulate the transduction of facial pain by inhibiting P2X3 receptor in trigeminal ganglia. PMID: 22286789
    29. The data of this study suggested that the conserved tyrosine 37 links TM1 to TM2 of adjacent subunit to stabilize desensitized states and restricts calcium permeability through the ion channel. PMID: 21883226
    30. These results suggest that the upregulation of P2X(2), P2X(3) and/or P2X(2/3) receptor in DRG neurons is associated with mechanical allodynia in STZ-induced diabetic mice. PMID: 19383439
    31. P2X(3) labeling intensity and the numerical density in stellate ganglia of the experimental myocardial ischemic injury group were enhanced. PMID: 17462717
    32. These results indicate that a large enhancement of P2X3 receptor activity and an increase in the membrane expression of P2X3 receptors contribute to the development of chronic pain in streptozotocin-induced diabetic rats. PMID: 21851615
    33. Levels of P2X(3) in primary afferent neurons of the dorsal root ganglion are upregulated as the blood supply to the hindlimb is deficient under ischemic conditions, leading to augmentation of the muscle reflex. PMID: 21642505
    34. We conclude that, in newborn rats, P2X purinergic receptors are involved in the regulation of breathing under basal and hypoxic condition, and P2X-containing receptors play a major role in carotid body function. PMID: 21051571
    35. Results show that emodin can inhibit the transmission of neuropathic pain mediated by P2X(2/3) receptors of primary sensory neurons to alleviate chronic neuropathic pain. PMID: 21303687
    36. noradrenaline stimulates P2X3 expression in dorsal root ganglion neurons PMID: 21195750
    37. findings demonstrate that the activation of P2X3 and P2X2/3 receptors by endogenous ATP mediates bradykinin-induced mechanical hyperalgesia by a mechanism that does not depend on neutrophil migration or cytokines release PMID: 20868656
    38. The present findings suggest that activation of P2X3 and P2X2/3 receptors in the tooth pulp is sufficient to elicit nociceptive behavioral responses and trigeminal brainstem neuronal activity. PMID: 20860800
    39. Myocardial ischemic injury induces an increase in expression of P2X(2/3) receptor colocalization with tyrosine hydroxylase and a hypersensitivity state of superior cervical ganglion neurons to ATP, which led to increased sympathoexcitatory reflex. PMID: 20406659
    40. Data show that extracellular application of cAMP to rat sensory neurons inhibits P2X(3) receptors via a G protein-coupled mechanism in a use-dependent manner, indicating the neuronal expression of specific plasmalemmal cAMP receptor. PMID: 20121714
    41. the enhanced pain response caused by PAR2 activation is not through direct increase of the P2X3 current amplitude PMID: 20118742
    42. Presence of P2X3 receptor is demonstrated for the first time in rat otic neurons. PMID: 15081800
    43. P2X3 receptor localizes into lipid rafts in neuronal cells of rat cerebellum. PMID: 15139024
    44. neurones with P2X3 immunoreactivity coexpressed nitric oxide synthase throughout perinatal development PMID: 15258768
    45. electrical stimulation enhances the expression of P2X3 receptors in the membrane and the enhancement is blocked by CaMKII inhibitor PMID: 15292517
    46. P2X3 receptor expression in the developing cochlea is confined to spiral ganglion neurons within Rosenthal's canal of the cochlea and is evident in the neurite processes when synaptic determination is occurring. PMID: 15736235
    47. Immunostaining for P2X2 and P2X3 receptors in urothelium and detrusor smooth muscle whole mounts and spinal cord sections was examined. Western blot demonstrated an age-dependent decrease (R(2) = 0.96, P PMID: 15947072
    48. expression of P2X(2/3) receptors in rat superior cervical ganglion neurons during late embryonic and early post-natal development PMID: 15973739
    49. rat and mouse P2X3 and TRPV1 receptors have different mechanisms of mediating pain on trigeminal nociceptors PMID: 16566843
    50. The activation of the P2X3 receptor is involved in the phosphorylation of ERK in dorsal root ganglion neurons and the mechanical hypersensitivity of the inflamed knee joint. PMID: 16616417

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    P2X receptor family
  • 组织特异性：
    Selectively expressed in sensory ganglia.
  • 数据库链接：

    KEGG: rno:81739

    STRING: 10116.ENSRNOP00000031629

    UniGene: Rn.10388