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  4. Recombinant Rat Neuroserpin (Serpini1)

Recombinant Rat Neuroserpin (Serpini1)

  • 中文名称：
    大鼠Serpini1重组蛋白
  • 货号：
    CSB-YP867553RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Serpini1重组蛋白
  • 货号：
    CSB-EP867553RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Serpini1重组蛋白
  • 货号：
    CSB-EP867553RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Serpini1重组蛋白
  • 货号：
    CSB-BP867553RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Serpini1重组蛋白
  • 货号：
    CSB-MP867553RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Serpini1
  • Uniprot No.：
  • 别名：
    Serpini1; Pi12; Spi17Neuroserpin; Peptidase inhibitor 12; PI-12; Serine protease inhibitor 17; Serpin I1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    17-410
  • 氨基酸序列
    TGAA FPDETIAEWS VNVYNHLRAT GEDENILFSP LSIALAMGVM ELGAQGSTLK EIRHSMGYES LKSGEEFSFL RDFSSMVSAE EGQYVMKIAN SLFVQNGFHI NEEFLQMMKM YFNAEVNHVD FSENVAVANY INKWVENYTN SLLKDLVSPG DFDAVTHLAL INAVYFKGNW KSQFRPENTR TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE ISMMLVLSRQ EVPLATLEPL LKPQLIEEWA NSVKKQKVEV YLPRFTVEQE IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS FIEVNEEGSE AAVASGMIAI SRMAVLFPQV IVDHPFLFLI KNRKTGTILF MGRVMHPETM NTSGHDFEEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
  • 基因功能参考文献：
    1. neuroserpin has a role in oxygen-glucose deprivation- and reoxygenation-treated rat astrocytes PMID: 25874935
    2. The majority of the mutant neuroserpin proteins were found to fold correctly and could still form inhibitory complexes with tissue plasminogen activator (tPA). PMID: 25363759
    3. Neuroserpin upregulates in the early period of sustained spinal cord compression. PMID: 23163103
    4. Increased expression of neuroserpin is shown to regulate the density of dendritic protrusions and shift morphology to a more immature spine phenotype. PMID: 20648651
    5. Although neuroserpin is expressed during late stage of neurogenesis in development, our results suggest that neuroserpin may play some roles in early stage of neurogenesis in adult rat hippocampus. PMID: 20010310
    6. novel intracellular serpin from the rat pituitary gland; data suggest raPIT5a may regulate apoptosis in the pituitary by inhibition of granzyme B or GLP IIIa, or members of the caspase enzyme family. PMID: 11935397
    7. neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration PMID: 12438159
    8. In nerve cells, neuroserpin may regulate the levels of N-cadherin available for construction, maintenance, and control of synapses and synaptic dynamics. PMID: 18092357

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  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon.
  • 蛋白家族：
    Serpin family
  • 组织特异性：
    Detected in adult pituitary and adrenal gland.
  • 数据库链接：

    KEGG: rno:116459

    STRING: 10116.ENSRNOP00000013905

    UniGene: Rn.52632