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Recombinant Rat Neuronal regeneration-related protein (Nrep)

  • 中文名称：
    大鼠Nrep重组蛋白
  • 货号：
    CSB-YP770500RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nrep重组蛋白
  • 货号：
    CSB-EP770500RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nrep重组蛋白
  • 货号：
    CSB-EP770500RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nrep重组蛋白
  • 货号：
    CSB-BP770500RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nrep重组蛋白
  • 货号：
    CSB-MP770500RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nrep
  • Uniprot No.：
  • 别名：
    Nrep; P311; Neuronal regeneration-related protein; Neuronal protein 3.1; Protein p311
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-68
  • 氨基酸序列
    MVYYPELLVW VSQEPFPYKE MEGGLTKGRL PVPKEVNRKK MDEPIAASLI PPGNHEPGSP AIGYLHPF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May have roles in neural function. Ectopic expression promotes axonal regeneration. Augments also motility of gliomas. May also have roles in cellular differentiation. Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.
  • 基因功能参考文献：
    1. P311 may be involved in the pathogenesis of renal fibrosis by blocking TGF-beta1-mediated epithelial-mesenchymal transition via TGF-beta1-Smad-ILK pathway in unilateral ureteral occlusion kidneys. PMID: 29436600
    2. efficiently blocked Smad-ILK pathway activation and attenuated epithelial-mesenchymal transition induced by TGF-beta1 PMID: 26559022
    3. P311 gene, together with alpha-SMA and TGF-beta1 genes, was induced in the process of Tubular epithelial-myofibroblast transition (TEMT) in rat. PMID: 26335191
    4. identified a gene, previously designated P311, up-regulated in axotomized facial motoneurons; ectopically expressed P311 localizes in the cytoplasm and the nucleus; over-expression of P311 induces p21(WAF1/Cip1), leading PC12 cells to differentiate [P311] PMID: 15485502
  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    KEGG: rno:338475

    STRING: 10116.ENSRNOP00000027739

    UniGene: Rn.8180