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  4. Recombinant Rat Neuronal acetylcholine receptor subunit beta-2 (Chrnb2), partial

Recombinant Rat Neuronal acetylcholine receptor subunit beta-2 (Chrnb2), partial

  • 中文名称：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-2(Chrnb2),partial,Yeast
  • 货号：
    CSB-YP005396RA1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-2(Chrnb2),partial,Yeast
  • 货号：
    CSB-EP005396RA1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-2(Chrnb2),partial,Yeast
  • 货号：
    CSB-EP005396RA1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-2(Chrnb2),partial,Yeast
  • 货号：
    CSB-BP005396RA1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-2(Chrnb2),partial,Yeast
  • 货号：
    CSB-MP005396RA1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Chrnb2
  • Uniprot No.：
  • 别名：
    Chrnb2; Acrb2; Neuronal acetylcholine receptor subunit beta-2; Neuronal acetylcholine receptor non-alpha-1 chain; N-alpha 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
  • 基因功能参考文献：
    1. Study shows that alpha6beta2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty PMID: 28666811
    2. Data show that although two cholinergic receptor nicotinic beta subunit 2 (beta2 subunit) mutations, F119Q and T59K, strongly enhanced the affinity of alpha-Conotoxin LvIA (LvIA), the beta2 mutation V111I substantially reduced the binding of LvIA. PMID: 25713061
    3. Artificial food colors and additives led to an increase in NR2B and nAChR beta2 receptor subunits in male rats and led to decrease in NR2B subunits in female rats. PMID: 23429044
    4. alpha4beta2 nicotinic cholineertgic receptor is involved ;in behavioral impairments induced by repeated electroconvulsive seizures in rats. PMID: 23219030
    5. We propose that the enhanced expression of beta2 nAChR by astrocytes stimulated directly by nanomolar concentrations of Abeta(1-42) might be related to ongoing defensive or compensative mechanisms PMID: 15955596
    6. Mutation of F342, L343, L349, & L350 to alanine in the beta2 AChR subunit abolishes cell surface expression of mutant alpha4beta2 AChRs. There may be an obligatory role for the beta2 AChR subunit in ER export. PMID: 16014729

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Beta-2/CHRNB2 sub-subfamily
  • 组织特异性：
    Expressed in most regions of the CNS.
  • 数据库链接：

    KEGG: rno:54239

    STRING: 10116.ENSRNOP00000028200

    UniGene: Rn.53978