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  4. Recombinant Rat Neuroendocrine protein 7B2 (Scg5)

Recombinant Rat Neuroendocrine protein 7B2 (Scg5)

  • 中文名称：
    大鼠Scg5重组蛋白
  • 货号：
    CSB-YP020810RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Scg5重组蛋白
  • 货号：
    CSB-EP020810RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Scg5重组蛋白
  • 货号：
    CSB-EP020810RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Scg5重组蛋白
  • 货号：
    CSB-BP020810RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Scg5重组蛋白
  • 货号：
    CSB-MP020810RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Scg5
  • Uniprot No.：
  • 别名：
    Scg5; Sgne1Neuroendocrine protein 7B2; Secretogranin V; Secretogranin-5; Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-210
  • 氨基酸序列
    YSPRTP DRVSETDIQR LLHGVMEQLG IARPRVEYPA HQAMNLVGPQ SIEGGAHEGL QHLGPFGNIP NIVAELTGDN IPKDFSEDQG YPDPPNPCPL GKTADDGCLE NAPDTAEFSR EFQLDQHLFD PEHDYPGLGK WNKKLLYEKM KGGQRRKRRS VNPYLQGKRL DNVVAKKSVP HFSEEEKEPE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
  • 基因功能参考文献：
    1. Acute exposure of MIN6 cells transduced with rat 7B2 to high glucose increased endogenous 7B2 biosynthesis without affecting the levels of its mRNA. PMID: 21805245
    2. phosphorylation of 7B2 functionally inactivates this protein in a manner analogous to the phosphorylating inactivation of BiP, which impairs its ability to bind substrate PMID: 16286464
  • 亚细胞定位：
    Secreted. Note=Neuroendocrine and endocrine secretory granules.
  • 蛋白家族：
    7B2 family
  • 数据库链接：

    KEGG: rno:25719

    STRING: 10116.ENSRNOP00000010679

    UniGene: Rn.6173