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  4. Recombinant Rat Neuritin (Nrn1)

Recombinant Rat Neuritin (Nrn1)

  • 中文名称：
    大鼠Nrn1重组蛋白
  • 货号：
    CSB-YP016088RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nrn1重组蛋白
  • 货号：
    CSB-EP016088RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nrn1重组蛋白
  • 货号：
    CSB-EP016088RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nrn1重组蛋白
  • 货号：
    CSB-BP016088RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nrn1重组蛋白
  • 货号：
    CSB-MP016088RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nrn1
  • Uniprot No.：
  • 别名：
    Nrn1; Neuritin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-116
  • 氨基酸序列
    AGK CDAVFKGFSD CLLKLGDSMA NYPQGLDDKT NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN LNIQGSLFEL CGSGNG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
  • 基因功能参考文献：
    1. The anti-apoptotic effect of IGF1 on Schwann cells inflicted by hyperglycemia is mediated at least by neuritin. PMID: 27966079
    2. Recombinant neuritin affects the senescence, apoptosis, proliferation, migration of rat bone marrow-derived mesenchymal stem cells. These findings offer new insight into neuritin function outside of the nervous system. PMID: 28852892
    3. Viral-mediated expression of neuritin in the dentate gyrus of 7-week-old Sprague-Dawley rats increased neurogenesis in the hippocampus. PMID: 25101829
    4. MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression PMID: 25036738
    5. The data demonstrate a novel function of Nrn1 in promoting migration of neuronal cells and indicate that Nrn1 levels impact on microtubule stability. PMID: 23212301
    6. Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress PMID: 22733766
    7. The expression of Neuritin protein in the visual cortex of rats in the monocular deprived group was considerably lower than that of the normal control group. PMID: 22177131
    8. Manipulation of neuritin levels in diabetes may provide a potential target for therapeutic intervention in the management of neuropathy. PMID: 17909094

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse.
  • 蛋白家族：
    Neuritin family
  • 组织特异性：
    Expressed predominantly in brain (at protein level). Highest expression in the dentate gyrus and lowest expression in the striatum. Concentrated on neuronal cell bodies and unevenly dispersed along neuritic projections in the nonmyelinated regions of the
  • 数据库链接：

    KEGG: rno:83834

    STRING: 10116.ENSRNOP00000066878

    UniGene: Rn.3546