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  4. Recombinant Rat Myeloid differentiation primary response protein MyD88 (Myd88)

Recombinant Rat Myeloid differentiation primary response protein MyD88 (Myd88)

  • 中文名称：
    大鼠Myd88重组蛋白
  • 货号：
    CSB-YP744333RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Myd88重组蛋白
  • 货号：
    CSB-EP744333RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Myd88重组蛋白
  • 货号：
    CSB-EP744333RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Myd88重组蛋白
  • 货号：
    CSB-BP744333RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Myd88重组蛋白
  • 货号：
    CSB-MP744333RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Myd88; Myeloid differentiation primary response protein MyD88
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-296
  • 氨基酸序列
    MSAGGPRVGS VSVDSYLFSL PLVALNVGVR RRLSLFLNPR TTAAADWTSL AEEMGFEYLE IREFETRPDP TRSLLDAWQG RSGSSVGRLL ELLALLDRED ILYELKDRIE EDCQKYIRNQ QKQESEKPLQ VARVESSVPQ TKELGGITTL DDPLGQTPEL FDAFICYCPS DIEFVQEMIR QLEQTDYRLK LCVSDRDVLP GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA LSLSPGVQQK RLIPIKYKAM KKDFPSILRF ITICDYTNPC TKSWFWTRLA KALSLP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
  • 基因功能参考文献：
    1. n-3 PUFAs may reduce acute RE in rats, which may be due to inhibition of the MyD88-NF-kB pathway and limit oxidative damage. PMID: 27716366
    2. this study shows that Myd88 expression is up-regulated in experimental periodontitis PMID: 27107801
    3. Results suggest that the myeloid differentiation factor 88 (MyD88) pathway plays a critical role in their immune defense activity. PMID: 26684858
    4. High MYD88 expression is associated with corneal allograft rejection after penetrating keratoplasty. PMID: 25800037
    5. Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via MyD88-TLR7 signaling. PMID: 26363072
    6. The study aims to detect the expression level of MyD88 and know more about the role of MyD88 after Subarachnoid hemorrhage PMID: 23684713
    7. Myd88 is increasingly expressed in a parallel time course to the up-regulation of nuclear factor-kappaB, proinflammatory cytokines and ICAM-1; there is a highly positive relationship among them. PMID: 21530945
    8. disruption of MyD88 or TRIF signaling does not confer protection in brain ischemia PMID: 21376021
    9. Intrauterine LPS infusion can induce an increased expression levels of TLR4 and MyD88 in the lung PMID: 20021788
    10. Our results suggest that MyD88 is an important component in the Toll-like receptor-4-mediated nuclear factor-kappaB activation pathway that contributes to the development of cardiac hypertrophy. PMID: 16199478
    11. The results demonstrate that both inhibition of the NFkappaB activation pathway and activation of the Akt signaling pathway may be responsible for the protective effect of transfection of dominant negative MyD88. PMID: 16259957
    12. Absence of MyD88 enhances the tolerogenicity of dendritic cells (DCs) and suggest that inhibiting innate immunity may be a potential strategy to facilitate induction of transplant tolerance by DCs. PMID: 18589162
    13. Results suggest that Der p2 activates the MyD88 signaling pathway through toll-like receptor (TLR) 2, and induces asthma through the MyD88 signaling pathway in respiratory tissue. PMID: 19326394
    14. Myd88-dependent Nf-kB activation is involved in fibrinogen-induced hyperrophic response of cardiomyocytes. PMID: 19342961

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 数据库链接：

    KEGG: rno:301059

    STRING: 10116.ENSRNOP00000018341

    UniGene: Rn.37341