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  4. Recombinant Rat Leucine-rich glioma-inactivated protein 1 (Lgi1)

Recombinant Rat Leucine-rich glioma-inactivated protein 1 (Lgi1)

  • 中文名称：
    大鼠Lgi1重组蛋白
  • 货号：
    CSB-YP818360RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Lgi1重组蛋白
  • 货号：
    CSB-EP818360RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Lgi1重组蛋白
  • 货号：
    CSB-EP818360RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Lgi1重组蛋白
  • 货号：
    CSB-BP818360RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Lgi1重组蛋白
  • 货号：
    CSB-MP818360RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Lgi1Leucine-rich glioma-inactivated protein 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    35-557
  • 氨基酸序列
    KKPAKP KCPAVCTCSK DNALCENARS IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS NSFDVISDDA FIGLPHLEYL FIENNNIKSI SRHTFRGLKS LIHLSLANNN LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK LKWLVEWLGH TNATVEDIYC EGPPEYKKRK INSLSPKDFD CIITEFAKSQ DLPYQSLSID TFSYLNDEYV VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IDTQLYVIVA QLFGGSHIYK RDGFANKFIK IQDIEVLKIR KPNDIETFKI EDNWYFVVAD SSKAGFTTIY KWNGNGFYSH QSLHAWYRDT DVEYLEIARP PLTLRTPHLI LSSSSQRPVI YQWSKATQLF INQTDIPNME DVYAVKHFSV KGDVYICLTR FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ PLQINNYQYA ILGSDYSFTQ VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS FKGNTQIYKH VIVDLSA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors.
  • 基因功能参考文献：
    1. These results of this study suggest that Lgi1(L385R/+) rats are useful as an animal model of human autosomal dominant lateral temporal lobe epilepsy. PMID: 24406746
    2. LGI1 epilepsy-causing missense mutations might cause a depletion of the protein in neurons, and not only a failure of Lgi1 secretion. PMID: 22589250
    3. The Lgi1 is a cytoplasmic protein distributed both in the soma and in the processes of neurons. PMID: 19756693
    4. ADAM22, a transmembrane protein that when mutated causes seizure, serves as a receptor for LGI1; LGI1 enhances AMPA receptor-mediated synaptic transmission in hippocampal slices; mutated form of LGI1 fails to bind to ADAM22 PMID: 16990550
  • 亚细胞定位：
    Secreted. Cell junction, synapse.
  • 组织特异性：
    Expressed in brain. High levels found in hippocampus, thalamic nuclei, neocortex, and molecular and granule cell layers of the cerebellum.
  • 数据库链接：

    KEGG: rno:252892

    STRING: 10116.ENSRNOP00000020411

    UniGene: Rn.83615