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  4. Recombinant Rat Krueppel-like factor 2 (Klf2)

Recombinant Rat Krueppel-like factor 2 (Klf2)

  • 中文名称：
    大鼠Klf2重组蛋白
  • 货号：
    CSB-YP875373RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Klf2重组蛋白
  • 货号：
    CSB-EP875373RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Klf2重组蛋白
  • 货号：
    CSB-EP875373RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Klf2重组蛋白
  • 货号：
    CSB-BP875373RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Klf2重组蛋白
  • 货号：
    CSB-MP875373RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Klf2; LklfKrueppel-like factor 2; Lung krueppel-like factor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-351
  • 氨基酸序列
    MALSEPILPS FATFASPCER GLQERWPRNE PEAGSTDEDL NSVLDFILSM GLDGLGAENP PEPPPQPPPP AFYYPEPGAP PPYGTPAAGL GTELLRPDLD APQGPALHGR FLLAPPGRLV KAEPPEVDGG GYGCAAGLAR GPRGLKLEGA LGATGACMRG PAGRPPPPSD TPPLSPDGPP RLPAPGPRNP FPPPFGPGPS FGGPGPALHY GPPAPGAFGL FDDAAAALGL APPATRGLLT PPSSPLELLE AKPKRGRRSW PRKRAATHTC SYTNCGKTYT KSSHLKAHLR THTGEKPYHC NWDGCGWKFA RSDELTRHYR KHTGHRPFQC HLCDRAFSRS DHLALHMKRH M
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.
  • 基因功能参考文献：
    1. KLF2 was remarkably downregulated in bleomycin-treated rats, both in mRNA and protein levels. Additionally, overexpression of KLF2 attenuated the destruction of the alveolar space and pulmonary interstitial collagen hyperplasia. PMID: 29079188
    2. Transcription factor Kruppel-like factor 2 (KLF2) of the zinc finger family of DNA-binding proteins has recently emerged as a major molecular switch that controls endothelial homeostasis PMID: 27855271
    3. Cirrhotic rats treated with simvastatin showed hepatic up regulation in KLF2 protein and reduction in liver fibrosis. PMID: 25500203
    4. Upregulation of hepatic endothelial KLF2-derived transcriptional programs by statins confers vasoprotection and stellate cells deactivation. PMID: 22989565
    5. The expression of KLF2 is significantly up-regulated in chronic obstructive pulmonary disease. PMID: 22737924
    6. results provide evidence for the first time that lung kruppel like factor is down-regulated in the later stages of lung development, may impair lung development and maturation, resulting in pulmonary hypoplasia in the nitrofen CDH model. PMID: 21053160
    7. LKLF gene is not defective in diabetic prone BB rats and its expression is not compromised by mutation. (Klf2) PMID: 15033788

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 数据库链接：

    KEGG: rno:306330

    STRING: 10116.ENSRNOP00000019052

    UniGene: Rn.92653