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  4. Recombinant Rat Interleukin-1 receptor antagonist protein (Il1rn)

Recombinant Rat Interleukin-1 receptor antagonist protein (Il1rn)

  • 货号：
    CSB-YP011628RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011628RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011628RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011628RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011628RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Il1rn
  • Uniprot No.：
  • 别名：
    Il1rn; Il-1raInterleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IRAP; IL1 inhibitor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-178
  • 氨基酸序列
    HPAG KRPCKMQAFR IWDTNQKTFY LRNNQLIAGY LQGPNTKLEE KIDMVPIDFR NVFLGIHGGK LCLSCVKSGD DTKLQLEEVN ITDLNKNKEE DKRFTFIRSE TGPTTSFESL ACPGWFLCTT LEADHPVSLT NTPKEPCTVT KFYFQEDQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
  • 基因功能参考文献：
    1. IL-1beta is the key trigger of neuroinflammation and that IL-1ra prevents the neuroinflammation entering the chronic state PMID: 24621600
    2. Interleukin-1beta and interleukin-1 receptor antagonist appear in grey matter additionally to white matter during experimental multiple sclerosis PMID: 24376764
    3. Gene expression of the natural IL-1 receptor antagonist IL-1ra and IL-18 (but not TNFalpha) is increased in the ipsilateral hippocampus during long-term potentiation. PMID: 23747799
    4. the IL-1ra gene could be transferred and expressed in corneal tissue efficiently. This may be a novel technique for gene transfection to the cornea in situ. PMID: 22827713
    5. Energy-sensing factors coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist. PMID: 22117073
    6. IL1Ra has a role in reducing islet endothelial activation and oxidative stress gene expression in the GK diabetic rat PMID: 19742300
    7. IL-1ra, even when applied for only 4 h, reduces neuronal cell death and the number of microglial cells after excitotoxic damage PMID: 15932594
    8. rhIL-1ra may protect renal injury after asphyxia via inhibiting intrarenal inflammatory response. PMID: 16259926
    9. IL-1ra is a modulator of gender differences in the febrile response to lipopolysaccharides. PMID: 17138728
    10. physical training has an effect on IL-1beta, IL-6 and IL-1ra concentrations in various brain areas of the rat PMID: 18299269
    11. Estrogen-induced protection is associated with a decrease in IL-1beta and an increase in IL-1ra expression in the ischemic hippocampus which suggests that modulation of IL-1beta/IL-1ra might be a part of anti-inflammatory effects of estrogen. PMID: 18455872
    12. A pro-inflammatory orientation in the interleukin-1 beta/interleukin-1 receptor antagonist balance might play a role in the initiation of perinatal brain damages. PMID: 18511291

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-1 family
  • 数据库链接：

    KEGG: rno:60582

    STRING: 10116.ENSRNOP00000007949

    UniGene: Rn.162640