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  4. Recombinant Rat Hepatocyte nuclear factor 1-alpha (Hnf1a)

Recombinant Rat Hepatocyte nuclear factor 1-alpha (Hnf1a)

  • 中文名称：
    大鼠Hnf1a重组蛋白
  • 货号：
    CSB-YP010592RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Hnf1a重组蛋白
  • 货号：
    CSB-EP010592RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Hnf1a重组蛋白
  • 货号：
    CSB-EP010592RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Hnf1a重组蛋白
  • 货号：
    CSB-BP010592RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Hnf1a重组蛋白
  • 货号：
    CSB-MP010592RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Hnf1a; Hnf-1; Hnf-1a; Tcf1; Hepatocyte nuclear factor 1-alpha; HNF-1-alpha; HNF-1A; Liver-specific transcription factor LF-B1; LFB1; Transcription factor 1; TCF-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-628
  • 氨基酸序列
    MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLMVG DGPLDKGESC GGTRGDLTEL PNGLGETRGS EDDTDDDGED FAPPILKELE NLSPEEAAHQ KAVVESLLQE DPWRVAKMVK SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYNGPP PGPGPGPALP AHSSPGLPTT TLSPSKVHGV RYGQSATSEA AEVPSSSGGP LVTVSAALHQ VSPTGLEPSS LLSTEAKLVS ATGGPLPPVS TLTALHSLEQ TSPGLNQQPQ NLIMASLPGV MTIGPGEPAS LGPTFTNTGA STLVIGLAST QAQSVPVINS MGSSLTTLQP VQFSQPLHPS YQQPLMPPVQ SHVAQSPFMA TMAQLQSPHA LYSHKPEVAQ YTHTSLLPQT MLITDTNLST LASLTPTKQV FTSDTEASSE PGLHEPSSPA TTIHIPSQDP SNIQHLQPAH RLSTSPTVSS SSLVLYQSSD SNGHSHLLPS NHGVIETFIS TQMASSSQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11.
  • 基因功能参考文献：
    1. coordinated upregulation of genes encoding CRP, interleukin-6 (IL-6), HNF1alpha, and HNF4alpha in the livers and white adipose tissue (WAT) of chronic renal failure rats, as compared to the pair-fed and control animals. PMID: 29330688
    2. Hnf1alpha gene expression is upregulated in the liver of rats with experimentally induced chronic renal failure, showing an association between circulating PCSK9 and TAGs PMID: 26978583
    3. HNF-1alpha, HNF-4alpha and FOXA2 transcriptional factors are involved in diabetes-induced overexpression of Slc2a2 gene in the liver and kidney. PMID: 24157454
    4. De novo synthesis of HNF-1alpha was seen in rat brain, and an increased interaction of HNF-1alpha with p300 and albumin promoter seems to be responsible for overexpression of albumin in ischemic condition. PMID: 22196858
    5. Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress. PMID: 21784843
    6. a critical link between HNF1A-MODY-induced alterations in Bmp-3 expression and insulin gene levels PMID: 21628466
    7. Studies suggest that overexpression of DN-HNF1A induces bioenergetic stress and activation of AMPK, and this in turn mediates the transcriptional activation of BMF, coupling prolonged energy stress to apoptosis activation. PMID: 20841353
    8. analysis of isoform-specific expression of the human, mouse and rat HNF1A, HNF1B and HNF4A genes PMID: 19924231
    9. Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells PMID: 19933277
    10. CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes PMID: 15598887
    11. Inheritance eis assoiated with type 2 diabetes of the young, polycystic thyroid and urogenital malformations. PMID: 17337496
    12. HNF-1alpha, as a modulator of SGLT2 expression, may be involved in diabetic kidney disease PMID: 17962340
    13. major change in transcriptional control by HNF1 that affects redox and other genes and precedes emergence of hypertensive renal injury PMID: 18443232
    14. Renal transcription factors HNF1alpha, HNF1beta, and HIF-1 might be the central mediators of drug-induced kidney injury and adaptive response pathways. PMID: 18656965
    15. signalling through mTORC1 is highly sensitive to suppression of HNF1A function, and may contribute to disturbance of cell-size regulation and cell-cycle progression in HNF1A-maturity onset diabetes. PMID: 18949455
    16. in addition to reduced glycolytic flux, uncoupling of mitochondrial oxidative phosphorylation contributes to impaired nutrient-stimulated insulin secretion with either mutations or loss of HNF-1alpha PMID: 19376774
    17. The overexpression of the SLC2A2 gene in the kidney of diabetic rats is associated with the transcriptional activity of HNF-1alpha and HNF-3beta. PMID: 19433262

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HNF1 homeobox family
  • 组织特异性：
    Liver.
  • 数据库链接：

    KEGG: rno:24817

    STRING: 10116.ENSRNOP00000001565

    UniGene: Rn.9660