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  4. Recombinant Rat Guanylin (Guca2a)

Recombinant Rat Guanylin (Guca2a)

  • 中文名称：
    大鼠Guca2a重组蛋白
  • 货号：
    CSB-YP010047RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Guca2a重组蛋白
  • 货号：
    CSB-EP010047RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Guca2a重组蛋白
  • 货号：
    CSB-EP010047RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Guca2a重组蛋白
  • 货号：
    CSB-BP010047RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Guca2a重组蛋白
  • 货号：
    CSB-MP010047RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Guca2a
  • Uniprot No.：
  • 别名：
    Guca2a; Guca2; Guanylin; Guanylate cyclase activator 2A
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    101-115
  • 氨基酸序列
    PNTCEICAYA ACTGC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
  • 基因功能参考文献：
    1. These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance PMID: 29097254
    2. The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines. PMID: 27044258
    3. Data (including data from studies in transgenic rats) suggest guanylin--guanylyl cyclase-C signaling in macrophages in mesenteric fat regulates cGMP--PKG--VASP pathway and mesenteric panniculitis/obesity via down-regulation of proinflammatory factors. PMID: 26249840
    4. the macrophagic guanylin-GC-C system contributes to the altered expression of genes involved in lipid metabolism, leading to resistance to obesity PMID: 23081987
    5. guanylin is synthesized as an intrinsic peptide in epithelial cells of the hepatobiliary system and released luminally into the hepatic and cystic bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway PMID: 22310983
    6. The early diffuse guanylin immunoreactivity we observed in ducts and acinar anlage, before the secretory set is operative, suggests guanylin has a role in cell differentiation. (Guanylin) PMID: 14986129
    7. Guanylin plays a role in the regulation of ion transport in the colon PMID: 15901896
    8. atrial natriuretic peptide, urodilatin, guanylin and uroguanylin interact in rat kidney PMID: 16814407

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Guanylin family
  • 组织特异性：
    Intestine and in low abundance in adrenal gland, kidney, and uterus/oviduct.
  • 数据库链接：

    KEGG: rno:25656

    STRING: 10116.ENSRNOP00000011867

    UniGene: Rn.11388